caa a22 4500 46907860X CHVBK 20180323132942.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00169002 doi (NATIONALLICENCE)springer-10.1007/BF00169002 Effects of serotonin and noradrenaline on superficial hand veins in patients with primary hypertension and in healthy volunteers [Elektronische Daten] [Michael Wolzt, Edgar Schmidt, Brunhilde Wagner, Sanja Schuller-Petrovic, Paul Kyrle, Hans-Georg Eichler] Summary: In vitro and animal experiments suggest that a constitutional increase in vascular responsiveness to serotonin (5-HT) may play a role in the development of essential hypertension. We have studied the potential alterations in vascular responsiveness to the direct and catecholamine-potentiating effects of exogenous 5-HT in patients with essential hypertension, by comparing in vivo responsiveness of superficial hand veins to local infusions of 5-HT or to coinfusions of 5-HT and noradrenaline in unmedicated hypertensive patients and in healthy control subjects. The dorsal hand vein compliance technique was employed. There was no significant difference between patients and control subjects in the maximal 5-HT-induced venoconstriction or in the doses required for half-maximal venoconstriction (ED50) for 5-HT. Coinfusions of a constant dose of 5-HT caused a significant leftward shift in the dose response curve for noradrenaline as compared with noradrenaline alone. This was indicated by a 9.7±13.7 fold and a 10.4±13.8 fold increase in the ED50 for noradrenaline in the patient and control groups, respectively (p = 0.89 between study groups). Our results argue against a generalized increase in responsiveness to the direct or catecholamine-potentiating effect of 5-HT in vivo in vascular smooth muscle, associated with hypertension. Springer-Verlag, 1992 Hypertension nationallicence Serotonin nationallicence Veins nationallicence Human nationallicence In vivo nationallicence Wolzt Michael Department of Clinical Pharmacology, Vienna University Hospital, Vienna, Austria aut Schmidt Edgar Department of Clinical Pharmacology, Vienna University Hospital, Vienna, Austria aut Wagner Brunhilde Department of Clinical Pharmacology, Vienna University Hospital, Vienna, Austria aut Schuller-Petrovic Sanja Department of Dermatology II, Vienna University Hospital, Vienna, Austria aut Kyrle Paul Division of Haematology and Haemostasis/Department of Internal Medicine I, Vienna University Hospital, Vienna, Austria aut Eichler Hans-Georg Department of Clinical Pharmacology, Vienna University Hospital, Vienna, Austria aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/5(1992-11-01), 490-495 0028-1298 346:5<490 1992 346 210 https://doi.org/10.1007/BF00169002 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00169002 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wolzt Michael Department of Clinical Pharmacology, Vienna University Hospital, Vienna, Austria aut NATIONALLICENCE 700 1- Schmidt Edgar Department of Clinical Pharmacology, Vienna University Hospital, Vienna, Austria aut NATIONALLICENCE 700 1- Wagner Brunhilde Department of Clinical Pharmacology, Vienna University Hospital, Vienna, Austria aut NATIONALLICENCE 700 1- Schuller-Petrovic Sanja Department of Dermatology II, Vienna University Hospital, Vienna, Austria aut NATIONALLICENCE 700 1- Kyrle Paul Division of Haematology and Haemostasis/Department of Internal Medicine I, Vienna University Hospital, Vienna, Austria aut NATIONALLICENCE 700 1- Eichler Hans-Georg Department of Clinical Pharmacology, Vienna University Hospital, Vienna, Austria aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/5(1992-11-01), 490-495 0028-1298 346:5<490 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer