caa a22 4500 469078707 CHVBK 20180323132943.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF00165292 doi (NATIONALLICENCE)springer-10.1007/BF00165292 Long lasting attenuation of 8-OH-DPAT induced corticosterone secretion after a single injection of a 5-HT1A receptor agonist [Elektronische Daten] [Diana Kelder, Svante Ross] Summary: The effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and some other 5-hydroxytryptamine1A (5-HT1A) receptor agonists (buspirone, ipsapirone and flesinoxan) on corticosterone secretion in rats were studied. The 5-HT1A receptors mediating the corticosterone secretion appear to be postsynaptic to the 5-HT neurons, since the response to 8-OH-DPAT was not decreased but potentiated by depletion of 5-HT with p-chlorophenylalanine pretreatment of the animals. Rapid attenuation of the response was developed after a single dose of a 5-HT1A receptor agonist. Thus, 1 mg/kg s.c. of 8-OH-DPAT attenuated the response of a challenge dose (0.1 mg/kg s.c.) of this compound within 4 h lasting between 7 and 14 d. The development of the subsensitivity was antagonized by pretreatment of the rats with the 5-HT1A receptor antagonist S-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin ((−)-UH 301). This compound also antagonized the acute effect of 8-OH-DPAT in increasing serum corticosterone. The subsensitivity development was specific for the 5-HT1A receptor-mediated corticosterone secretion, since the increase in serum corticosterone produced by stimulation of other receptor systems, e.g. α2-adrenoreceptors (clonidine) or 5-HT2 receptors [1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, (DOI)] was not affected. Springer-Verlag, 1992 5-HT1A receptors nationallicence Attenuation nationallicence Corticosterone nationallicence 8-OH-DPAT nationallicence (−)-UH 301 nationallicence Kelder Diana Department of Neuropharmacology, Astra Arcus AB, S-151 85, Södertälje, Sweden aut Ross Svante Department of Neuropharmacology, Astra Arcus AB, S-151 85, Södertälje, Sweden aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/2(1992-08-01), 121-126 0028-1298 346:2<121 1992 346 210 https://doi.org/10.1007/BF00165292 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00165292 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kelder Diana Department of Neuropharmacology, Astra Arcus AB, S-151 85, Södertälje, Sweden aut NATIONALLICENCE 700 1- Ross Svante Department of Neuropharmacology, Astra Arcus AB, S-151 85, Södertälje, Sweden aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/2(1992-08-01), 121-126 0028-1298 346:2<121 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer