caa a22 4500 469078782 CHVBK 20180323132943.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF00165305 doi (NATIONALLICENCE)springer-10.1007/BF00165305 Hotzer-Petsche Ulrike Institut für Experimentelle und Klinische Pharmakologie, Karl-Franzens-Universität Graz, Universitätsplatz 4, A-8010, Graz, Austria aut Blood pressure and gastric motor responses to bradykinin and hydrochloric acid injected into somatic or visceral tissues [Elektronische Daten] [Ulrike Hotzer-Petsche] Summary: Both visceral and somatic nociceptive stimuli elicit reflex changes in blood pressure and gastric motor activity, but the exact type of response varies with the type of nociceptive stimulus and its site of application. Therefore, the present study compared the effects of visceral (i. p. or i. a.) and somatic (s. c.) administration of bradykinin and HCl on both mean arterial blood pressure (MAP) and intragastric pressure in anaesthetized rats. The nervous pathways mediating these responses were investigated by surgical or pharmacological inhibition of the possible reflex arcs. Bradykinin (i. a. — into the aortic arch, i. p., and s. c.), and HCI (i. p. and s. c.), elicited a fall in MAP followed by a transient increase. Intragastric pressure decreased in response to administration of these chemicals. Acute coeliac ganglionectomy reduced the gastric relaxations in response to both bradykinin and HCl, whereas vagotomy reduced only the gastric relaxations induced by HCl. Neither lesion influenced the changes in MAP after either chemical. Ablation of small diameter afferents by capsaicin or chemical sympathectomy by guanethidine reduced the changes in MAP after both chemicals, except that which occurred after i. a. injection of bradykinin. The secondary increase in MAP after i. a. and i. p. administration of algesics was increased after guanethidine. Both pretreatments reduced gastric relaxations in response to either chemical. Pretreatment of the rats with the bradykinin antagonist Hoe-140 reduced the responses to bradykinin but not to HCl. The results show that both visceral and somatic administration of painful chemicals elicit reflex falls in00 MAP and intragastric pressure. In general, the responses are stronger after "visceral” than after "somatic” administration. Both the splanchnic and vagal pathways seem to be involved in mediating the gastric motor responses. However, the effects of different algesics are not necessarily mediated by the same mechanisms. Springer-Verlag, 1992 Pain (somatic/visceral) nationallicence Nociception nationallicence Bradykinin nationallicence Capsaicin nationallicence Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/2(1992-08-01), 219-225 0028-1298 346:2<219 1992 346 210 https://doi.org/10.1007/BF00165305 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00165305 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hotzer-Petsche Ulrike Institut für Experimentelle und Klinische Pharmakologie, Karl-Franzens-Universität Graz, Universitätsplatz 4, A-8010, Graz, Austria aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/2(1992-08-01), 219-225 0028-1298 346:2<219 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer