caa a22 4500 469078804 CHVBK 20180323132943.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF00165294 doi (NATIONALLICENCE)springer-10.1007/BF00165294 N-Methyl-D-aspartate receptor antagonists counteract the long lasting 5-HT1A receptor-induced attenuation of postsynaptic responses in the rat in vivo [Elektronische Daten] [Svante Ross, Lucy Rényi, Diana Kelder] Summary: The effect of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists dizocilpine and phencyclidine, the competitive NMDA antagonist 3-(2-carboxypiperazin-4-yl)-propyl-l-phosphonic acid (CPP) and the antagonist at the glycine modulatory site of the NMDA receptor, 3-amino-l-hydroxy-2-pyrrolidone (HA-966) on the long lasting attenuation of some postsynaptic 5-HT1A receptor-mediated responses in rats (increased corticosterone secretion and inhibition of the cage leaving response) produced by a single injection of the 5-hydroxytryptamine1A 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) was studied. It was found that these antagonists counter-acted the attenuation of these responses at dose levels known to block the NMDA receptor-ion channel complex in vivo. It is concluded that the long lasting attenuation of postsynaptic responses after a 5-HT1A receptor agonist is initiated through stimulation of glutamate NMDA receptors indicating a functional interaction between the 5-HT and glutamate systems in at least two different models. Springer-Verlag, 1992 5-HT1A receptors nationallicence NMDA receptors nationallicence Dizocilpine nationallicence Phencyclidine nationallicence Corticosterone secretion nationallicence Ross Svante The Research Laboratories, Astra Arcus AB, S-151 85, Södertälje, Sweden aut Rényi Lucy The Research Laboratories, Astra Arcus AB, S-151 85, Södertälje, Sweden aut Kelder Diana The Research Laboratories, Astra Arcus AB, S-151 85, Södertälje, Sweden aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/2(1992-08-01), 138-143 0028-1298 346:2<138 1992 346 210 https://doi.org/10.1007/BF00165294 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00165294 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ross Svante The Research Laboratories, Astra Arcus AB, S-151 85, Södertälje, Sweden aut NATIONALLICENCE 700 1- Rényi Lucy The Research Laboratories, Astra Arcus AB, S-151 85, Södertälje, Sweden aut NATIONALLICENCE 700 1- Kelder Diana The Research Laboratories, Astra Arcus AB, S-151 85, Södertälje, Sweden aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/2(1992-08-01), 138-143 0028-1298 346:2<138 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer