caa a22 4500 469078812 CHVBK 20180323132943.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF00165308 doi (NATIONALLICENCE)springer-10.1007/BF00165308 Reversal by 3,3′,5-triido- l -thyronine of the working memory deficit, and the decrease in acetylcholine, glutamate and γ-aminobutyric acid induced by ethylcholine aziridinium ion in mice [Elektronische Daten] [Eiichi Abe, Shigeo Murai, Yoshikatsu Masuda, Hiroko Saito, Tadanobu Itoh] Summary: The effect of 3,3′,5-triiodo-l-thyronine (T3) on working memory in ethylcholine aziridinium ion (AF64A)-treated mice was studied in a delayed nonmatching to sample task using a T-maze. After behavioural testing was completed, mice were killed by microwave irradiation and regional brain levels of acetylcholine, aspartate, glutamate, glutamine, glycine, taurine, and γ-aminobutyric acid (GABA) were measured by high-performance liquid chromatography with electrochemical detection. Treatment with AF64A (7 nmol, i. c. v.) produced a deficit in working memory performance in the non-matching to sample task at 30 s delay, and decreased acetylcholine, glutamate, and GABA levels in the hippocampus, but not in the septum and cerebral cortex. Administration of T3 (0.3 mg/kg, p.o., once daily for 6 days) to AF64A-treated animals improved the deficit in working memory performance and reversed the decrease in acetylcholine, glutamate, and GABA levels in the hippocampus. These results indicate that the deficit in performance induced by AF64A can be improved by T3 administration. Springer-Verlag, 1992 3,3′,5-Triiodo- l -thyronine nationallicence Ethylcholine aziridinium ion (AF64A) nationallicence Acetylcholine nationallicence Glutamate nationallicence γ-Aminobutyric acid nationallicence Delayed non-matching to sample nationallicence Working memory nationallicence Abe Eiichi Department of Pharmacology, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, 020, Morioka, Japan aut Murai Shigeo Department of Pharmacology, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, 020, Morioka, Japan aut Masuda Yoshikatsu Department of Pharmacology, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, 020, Morioka, Japan aut Saito Hiroko Department of Pharmacology, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, 020, Morioka, Japan aut Itoh Tadanobu Department of Pharmacology, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, 020, Morioka, Japan aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/2(1992-08-01), 238-242 0028-1298 346:2<238 1992 346 210 https://doi.org/10.1007/BF00165308 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00165308 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abe Eiichi Department of Pharmacology, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, 020, Morioka, Japan aut NATIONALLICENCE 700 1- Murai Shigeo Department of Pharmacology, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, 020, Morioka, Japan aut NATIONALLICENCE 700 1- Masuda Yoshikatsu Department of Pharmacology, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, 020, Morioka, Japan aut NATIONALLICENCE 700 1- Saito Hiroko Department of Pharmacology, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, 020, Morioka, Japan aut NATIONALLICENCE 700 1- Itoh Tadanobu Department of Pharmacology, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, 020, Morioka, Japan aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/2(1992-08-01), 238-242 0028-1298 346:2<238 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer