caa a22 4500 469078839 CHVBK 20180323132943.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF00165304 doi (NATIONALLICENCE)springer-10.1007/BF00165304 Lidocaine has a narrow antiarrhythmic dose range against ventricular arrhythmias induced by programmed electrical stimulation in conscious postinfarction dogs [Elektronische Daten] [Kurt Krejcy, Gunther Krumpl, Hannes Todt, Gerhard Raberger] Summary: The aim of the present study was to investigate the dose-dependent antiarrhythmic efficacy of lidocaine against electrically induced tachycardias in conscious, chronically instrumented postinfarction dogs. Programmed electrical stimulation (PES) was performed in 16 dogs 8 to 21 days after a 4 h occlusion of the left anterior descending coronary artery (LAD). Infusion of saline in 8 control animals with sustained ventricular tachycardia (SVT) inducible at baseline did not affect subsequent inducibility. In the treatment group 7 of 8 animals responded with SVT and one exhibited ventricular fibrillation at baseline. After an initial bolus of 1 mg/kg lidocaine intravenously (i.v.), the drug was infused at infusion rates of 40, 80 and 120 μg/kg/min (i.v.). During 80 μg/kg/min lidocaine (mean plasma level 3.5 μg/ml) 7 out of 8 animals displayed an antiarrhythmic response; both the lower and the higher infusion rate were associated with a smaller antiarrhythmic efficacy (3 of 8 animals responded to 40 μg/kg/min and 4 of 8 to 120 μg/kg/min). Licocaine did not affect ventricular refractory periods, but induced an increase in intraventricular conduction time at all infusion rates, from 66.2 ms at baseline to 67.7 ms (p<0.05), 67.7 ms (p<0.05), 70.0 ms (p<0.01) respectively. In conclusion the present study demonstrates that lidocaine is of considerable value in the management of PES-induced ventricular arrhythmias in the postinfarction phase. However there is only a small optimal therapeutic plasma level range, where lidocaine exhibits its antiarrhythmic efficacy against this type of arrhythmia; this makes a carefully titration of the drug necessary both in the experimental and in the clinical setting. Springer-Verlag, 1992 Lidocaine nationallicence Programmed electrical stimulation nationallicence Postinfarction phase nationallicence Conscious dogs nationallicence Krejcy Kurt Department of Cardiovascular Pharmacology, Institute of Pharmacology, University of Vienna, Wahringerstrasse 13A, A-1090, Vienna, Austria aut Krumpl Gunther Department of Cardiovascular Pharmacology, Institute of Pharmacology, University of Vienna, Wahringerstrasse 13A, A-1090, Vienna, Austria aut Todt Hannes Department of Cardiovascular Pharmacology, Institute of Pharmacology, University of Vienna, Wahringerstrasse 13A, A-1090, Vienna, Austria aut Raberger Gerhard Department of Cardiovascular Pharmacology, Institute of Pharmacology, University of Vienna, Wahringerstrasse 13A, A-1090, Vienna, Austria aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/2(1992-08-01), 213-218 0028-1298 346:2<213 1992 346 210 https://doi.org/10.1007/BF00165304 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00165304 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Krejcy Kurt Department of Cardiovascular Pharmacology, Institute of Pharmacology, University of Vienna, Wahringerstrasse 13A, A-1090, Vienna, Austria aut NATIONALLICENCE 700 1- Krumpl Gunther Department of Cardiovascular Pharmacology, Institute of Pharmacology, University of Vienna, Wahringerstrasse 13A, A-1090, Vienna, Austria aut NATIONALLICENCE 700 1- Todt Hannes Department of Cardiovascular Pharmacology, Institute of Pharmacology, University of Vienna, Wahringerstrasse 13A, A-1090, Vienna, Austria aut NATIONALLICENCE 700 1- Raberger Gerhard Department of Cardiovascular Pharmacology, Institute of Pharmacology, University of Vienna, Wahringerstrasse 13A, A-1090, Vienna, Austria aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 346/2(1992-08-01), 213-218 0028-1298 346:2<213 1992 346 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer