caa a22 4500 469079029 CHVBK 20180323132944.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF00175466 doi (NATIONALLICENCE)springer-10.1007/BF00175466 Bass Alan Committee on Clinical Pharmacology, Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 East 58th Street, 60637, Chicago, IL, USA aut Presynaptic effects of dopexamine hydrochloride in the canine kidney [Elektronische Daten] [Alan Bass] Summary: The effects of dopexamine on the vasoconstrictor response to renal nerve stimulation and noradrenaline were determined in anesthetized dogs. Renal vasoconstriction was repeated during the sequential administration of iso-osmotic saline, dopexamine, dopexamine plus the DA1-dopamine receptor antagonist, SCH 23390, and dopexamine plus SCH 23390 and the DA2-dopamine receptor antagonist, domperidone. Renal nerve stimulation-induced vasoconstriction did not change with dopexamine or dopexamine plus SCH 23390, but increased with the addition of domperidone. Dopexamine also potentiated noradrenaline-induced vasoconstriction. Antagonists alone had no affect on the vasoconstrictor response to either stimulus. The findings suggest that the absence of an effect of dopexamine on neuronally-induced renal vasoconstriction was a consequence of a balance between its actions at presynaptic DA2-dopamine receptors (attenuated vasoconstriction) and its ability to inhibit the uptake, transporter (enhanced vasoconstriction). Springer-Verlag, 1992 Dopexamine nationallicence Dog kidney nationallicence Dopamine receptors nationallicence Renal blood flow nationallicence Renal nerves nationallicence Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/1(1992-01-01), 33-36 0028-1298 345:1<33 1992 345 210 https://doi.org/10.1007/BF00175466 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00175466 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Bass Alan Committee on Clinical Pharmacology, Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 East 58th Street, 60637, Chicago, IL, USA aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/1(1992-01-01), 33-36 0028-1298 345:1<33 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer