caa a22 4500 46907907X CHVBK 20180323132944.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00164586 doi (NATIONALLICENCE)springer-10.1007/BF00164586 Inhibition of N-methyl- d -aspartate- and kainate-evoked noradrenaline release in human cerebral cortex slices by ethanol [Elektronische Daten] [Klaus Fink, Rolf Schultheiß, Manfred Göthert] Summary: The effect of ethanol on the release of noradrenaline evoked by various stimuli was investigated in human cerebral cortical slices from patients undergoing neurosurgery. The slices were preincubated with [3H]noradrenaline and then superfused. Tritium overflow was stimulated by exposure to N-methyl-d-aspartate (NMDA; in slices superfused without Mg2+), kainic acid, veratridine or by increasing the K+ concentration. The NMDA evoked tritium overflow was concentration-dependently inhibited by ethanol; an inhibition by 37% occurred at 48 mmol/l ethanol. This ethanol concentration was not yet effective when kainic acid was used for stimulation, but ethanol 150 mmol/l strongly inhibited the tritium overflow evoked by kainic acid as well. The tritium overflow evoked by veratridine or high K+ was not affected by ethanol in the concentration range investigated. These findings are compatible with the suggestion that the NMDA receptor and, with less susceptibility, the kainate receptor are sites of action underlying the effect of ethanol in the human brain. Springer-Verlag, 1992 Ethanol nationallicence Human cerebral cortex nationallicence NMDA receptor nationallicence Kainate receptor nationallicence Noradrenaline release nationallicence Fink Klaus Institute of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2b, W-5300, Bonn, Federal Republic of Germany aut Schultheiß Rolf Clinic of Neurosurgery, University of Bonn, Sigmund-Freud-Strasse 25, W-5300, Bonn, Federal Republic of Germany aut Göthert Manfred Institute of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2b, W-5300, Bonn, Federal Republic of Germany aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/6(1992-06-01), 700-703 0028-1298 345:6<700 1992 345 210 https://doi.org/10.1007/BF00164586 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00164586 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fink Klaus Institute of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2b, W-5300, Bonn, Federal Republic of Germany aut NATIONALLICENCE 700 1- Schultheiß Rolf Clinic of Neurosurgery, University of Bonn, Sigmund-Freud-Strasse 25, W-5300, Bonn, Federal Republic of Germany aut NATIONALLICENCE 700 1- Göthert Manfred Institute of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2b, W-5300, Bonn, Federal Republic of Germany aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/6(1992-06-01), 700-703 0028-1298 345:6<700 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer