caa a22 4500 46907924X CHVBK 20180323132945.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00168689 doi (NATIONALLICENCE)springer-10.1007/BF00168689 Prejunctional muscarine receptors in the rabbit ear artery differ from M1, M2 and M3 muscarine receptors [Elektronische Daten] [S. Darroch, L. Choo, F. Mitchelson] Summary: The ability of several selective muscarine receptor antagonists to inhibit the effect of carbachol on prejunctional muscarine receptors on sympathetic nerve endings in the rabbit isolated ear artery was investigated to characterise the receptor subtype involved. Carbachol did not reduce responses to exogenous noradrenaline and the inhibitory effect of carbachol on responses to nerve stimulation was unaffected by hexamethonium (10 μM) indicating that the effect of the muscarine agonist was exerted prejunctionally and was not modulated by nicotine receptor stimulation. The dissociation constants or apparent dissociation constants obtained using (±)-benzhexol (pKB; 6.63), (R)-benzhexol methiodide (8.11), dicyclomine (5.86), (±)-telenzepine (7.34), AF-DX 116 (6.95), himbacine (7.60), (±)-hexahydrosiladiphenidol (5.39) and a bisquaternary ammonium compound, heptane-1,7-bis(dimethyl-3′-phthalimidopropyl ammonium bromide) (5.84), indicate that the muscarine receptor subtype involved is not of the M1, M2 or M3 subtype. Springer-Verlag, 1992 Prejunctional muscarine receptors nationallicence Sympathetic nerves nationallicence Rabbit ear artery nationallicence Darroch S. School of Pharmacology, Victorian College of Pharmacy (Monash University), 381 Royal Parade, 3052, Parkville, Victoria, Australia aut Choo L. School of Pharmacology, Victorian College of Pharmacy (Monash University), 381 Royal Parade, 3052, Parkville, Victoria, Australia aut Mitchelson F. School of Pharmacology, Victorian College of Pharmacy (Monash University), 381 Royal Parade, 3052, Parkville, Victoria, Australia aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/3(1992-03-01), 288-295 0028-1298 345:3<288 1992 345 210 https://doi.org/10.1007/BF00168689 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00168689 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Darroch S. School of Pharmacology, Victorian College of Pharmacy (Monash University), 381 Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Choo L. School of Pharmacology, Victorian College of Pharmacy (Monash University), 381 Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 700 1- Mitchelson F. School of Pharmacology, Victorian College of Pharmacy (Monash University), 381 Royal Parade, 3052, Parkville, Victoria, Australia aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/3(1992-03-01), 288-295 0028-1298 345:3<288 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer