caa a22 4500 469079436 CHVBK 20180323132945.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF00176612 doi (NATIONALLICENCE)springer-10.1007/BF00176612 NPY and carbachol raise Ca2+ in SK-N-MC cells by three different mechanisms [Elektronische Daten] Evidence for inositol phosphate-independent Ca2+ mobilization by NPY [Martin Michel, Friedhelm Feth, Marion Stieneker, Wolfgang Raschera] Summary: We have compared the mechanism of NPY-and carbachol-stimulated Ca2+ increases in SK-N-MC cells. NPY stimulated Ca2+ mobilization via a pertussis toxin-sensitive mechanism. Carbachol stimulated Ca2+ mobilization and influx via pertussis toxin-insensitive and -sensitive mechanisms, respectively. Carbachol but not NPY stimulated inositol phosphate accumulation by a pertussis toxin-insensitive mechanism. We conclude that carbachol promotes Ca2+ influx via a pertussis toxin-sensitive G protein and Ca2+ mobilization via a pertussis toxin-insensitive G-protein coupling to inositol phosphate generation; NPY stimulates Ca2+ mobilization via a pertussis toxin-sensitive G protein without apparent involvement of inositol phosphates. Springer-Verlag, 1992 NPY receptor nationallicence Muscarinic acetylcholine receptor nationallicence Ca2+ nationallicence Inositol phosphates nationallicence Michel Martin Department of Medicine, University of Essen, Essen, Germany aut Feth Friedhelm Department of Pediatrics, University of Essen, Essen, Germany aut Stieneker Marion Department of Pediatrics, University of Essen, Essen, Germany aut Raschera Wolfgang Department of Pediatrics, University of Essen, Essen, Germany aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/4(1992-04-01), 370-374 0028-1298 345:4<370 1992 345 210 https://doi.org/10.1007/BF00176612 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00176612 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Michel Martin Department of Medicine, University of Essen, Essen, Germany aut NATIONALLICENCE 700 1- Feth Friedhelm Department of Pediatrics, University of Essen, Essen, Germany aut NATIONALLICENCE 700 1- Stieneker Marion Department of Pediatrics, University of Essen, Essen, Germany aut NATIONALLICENCE 700 1- Raschera Wolfgang Department of Pediatrics, University of Essen, Essen, Germany aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/4(1992-04-01), 370-374 0028-1298 345:4<370 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer