caa a22 4500 469079452 CHVBK 20180323132945.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF00176620 doi (NATIONALLICENCE)springer-10.1007/BF00176620 Relative contributions of ATP and noradrenaline to the nerve evoked contraction of the rabbit jejunal artery [Elektronische Daten] Dependence on stimulation parameters [R. Evans, T. Cunnane] Summary: Isotonic contractions of the rabbit jejunal artery were evoked by perivascular nerve stimulation with trains of 10 or 100 stimuli at 2 Hz or 10 Hz. Short trains of stimuli elicited contractions that were totally resistant to α-adrenoceptor blockade (0.1 μmol/l prazosin) but blocked by α,β-methylene ATP (1 μmol/l). A substantial noradrenergic component of contraction comprising about 50% of the total could be evoked by adjusting the stimulation parameters (increasing the frequency and/or number of stimuli in a train). The noradrenergic and the purinergic components are derived from sympathetic nerves as both were blocked by TTX and the adrenergic neurone blocker guanethidine (3 μmol/l). It is concluded that the contraction of the rabbit jejunal artery to short trains of stimuli is predominantly purinergic, a nor-adrenergic component only being revealed at higher frequencies of stimulation or during longer trains of stimuli. The purinergic component of contraction is derived from sympathetic nerves and not from a separate population of purinergic nerves. Springer-Verlag, 1992 Rabbit jejunal artery nationallicence Contraction nationallicence Cotransmission nationallicence ATP nationallicence Noradrenaline nationallicence Evans R. University Department of Pharmacology, Mansfield Road, OX1 3QT, Oxford, UK aut Cunnane T. Vellum Institute, Oregon Health Sciences University, 97201, Portland, OR, USA aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/4(1992-04-01), 424-430 0028-1298 345:4<424 1992 345 210 https://doi.org/10.1007/BF00176620 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00176620 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Evans R. University Department of Pharmacology, Mansfield Road, OX1 3QT, Oxford, UK aut NATIONALLICENCE 700 1- Cunnane T. Vellum Institute, Oregon Health Sciences University, 97201, Portland, OR, USA aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/4(1992-04-01), 424-430 0028-1298 345:4<424 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer