caa a22 4500 469079479 CHVBK 20180323132945.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF00176625 doi (NATIONALLICENCE)springer-10.1007/BF00176625 Inhibitory effects of the psychoactive drug modafinil on γ-aminobutyric acid outflow from the cerebral cortex of the awake freely moving guinea-pig [Elektronische Daten] Possible involvement of 5-hydroxytryptamine mechanisms [S. Tanganelli, K. Fuxe, L. Ferraro, A. Janson, C. Bianchi] Summary: The effects of modafmil on acetylcholine and GABA outflow from the cerebral cortex of awake freely moving guinea pigs provided with an epidural cup were studied. In the dose range of 3-30 mg/kg s. c. modafmil produced a dose dependent significant inhibition of GABA outflow without influencing cortical acetylcholine release. Methysergide (2 mg/kg, i.p.) and ketanserin (0.5 mg/kg, i. p.) but not prazosin (0.14 mg/kg, i. p.) counteracted the inhibitory action of modafinil on cortical GABA outflow. Modafinil both acutely and chronically in the same dose range increased striatal 5-HIAA levels and 5-HT utilization in the rat (acute) and mouse (chronic). The action on cortical GABA release may be dependent on activity at 5-HT2 receptors, since the action of modafmil in this respect is blocked by the non-selective 5-HT antagonist methysergide and the 5-HT2 antagonist ketanserin. The involvement of 5-HT mechanisms in the inhibitory action of modafmil on cortical GABA release is also suggested by the findings that 5-HT metabolism may become increased by modafmil at least in the striatum. The reduction of cortical GABA outflow via 5-HTZ receptors by modafmil is probably related to some of its actions on the central nervous system including behavioural effects. Springer-Verlag, 1992 Acetylcholine nationallicence GABA nationallicence 5-HT nationallicence 5-HT2 receptors nationallicence Metabolism nationallicence Cortical cup nationallicence Modafinil nationallicence Release nationallicence Tanganelli S. Department of Pharmacology, University of Ferrara, Ferrara, Italy aut Fuxe K. Department of Histology and Neurobiology, Karolinska Institutet, Box 60400, Stockholm, Sweden aut Ferraro L. Department of Pharmacology, University of Ferrara, Ferrara, Italy aut Janson A. Department of Histology and Neurobiology, Karolinska Institutet, Box 60400, Stockholm, Sweden aut Bianchi C. Department of Pharmacology, University of Ferrara, Ferrara, Italy aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/4(1992-04-01), 461-465 0028-1298 345:4<461 1992 345 210 https://doi.org/10.1007/BF00176625 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00176625 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tanganelli S. Department of Pharmacology, University of Ferrara, Ferrara, Italy aut NATIONALLICENCE 700 1- Fuxe K. Department of Histology and Neurobiology, Karolinska Institutet, Box 60400, Stockholm, Sweden aut NATIONALLICENCE 700 1- Ferraro L. Department of Pharmacology, University of Ferrara, Ferrara, Italy aut NATIONALLICENCE 700 1- Janson A. Department of Histology and Neurobiology, Karolinska Institutet, Box 60400, Stockholm, Sweden aut NATIONALLICENCE 700 1- Bianchi C. Department of Pharmacology, University of Ferrara, Ferrara, Italy aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/4(1992-04-01), 461-465 0028-1298 345:4<461 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer