caa a22 4500 469079568 CHVBK 20180323132946.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00168939 doi (NATIONALLICENCE)springer-10.1007/BF00168939 Inhibition of histamine turnover by 8-OH-DPAT, buspirone and 5-hydroxytryptophan in the mouse and rat brain [Elektronische Daten] [Ryozo Oishi, Yoshinori Roh, Kiyomi Saeki] Summary: The effects of 5-hydroxytryptamine (5-HT) receptor agonists on histamine turnover in mouse and rat brains were examined. The histamine turnover rate was estimated from the accumulation of tele-methylhistamine 90 min after i.p. injection of pargyline (65 mg/kg). In whole mouse brains, the histamine turnover was significantly inhibited by the 5-HT1A agonists, 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT) (> 0.5 mg/kg) and buspirone (> 2 mg/kg) injected s. c. 10 min before pargyline treatment. 5-hydroxytryptophan (20 mg/kg) also significantly inhibited histamine turnover. Injections of the 5-HT1B agonist m-trifluoromethylphenylpiperazine (10 and 20 mg/kg) or the 5-HT2 agonist (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (1, 2 and 5 mg/kg)), however, did not affect histamine turnover. The inhibitory effect of 8-OH-DPAT (1 mg/kg) on histamine turnover was significantly antagonized (by 40%) by pindolol (20 mg/kg) and slightly antagonized (by 29%) by spiperone (10 mg/kg), while methysergide (20 mg/kg) and ketanserin (10 mg/kg) demonstrated no antagonistic effects. 8-OH-DPAT (0.3 and 1 mg/kg) also showed an inhibiting effect on histamine turnover in various regions of rat brains. Although the extent of inhibition was slightly larger in the striatum and cerebral cortex, there was no marked regional difference. These results suggest that histaminergic activity in the brain is regulated by 5-HT1A receptors. Springer-Verlag, 1992 5-HT1A receptor nationallicence 8-OH-DPAT nationallicence Buspirone nationallicence Histamine turnover nationallicence Pindolol nationallicence Oishi Ryozo Department of Pharmacology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, Japan aut Roh Yoshinori Department of Pharmacology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, Japan aut Saeki Kiyomi Department of Pharmacology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, Japan aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/5(1992-05-01), 495-499 0028-1298 345:5<495 1992 345 210 https://doi.org/10.1007/BF00168939 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00168939 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oishi Ryozo Department of Pharmacology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, Japan aut NATIONALLICENCE 700 1- Roh Yoshinori Department of Pharmacology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, Japan aut NATIONALLICENCE 700 1- Saeki Kiyomi Department of Pharmacology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, Japan aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/5(1992-05-01), 495-499 0028-1298 345:5<495 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer