caa a22 4500 469079622 CHVBK 20180323132946.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00168945 doi (NATIONALLICENCE)springer-10.1007/BF00168945 The influence of the density of adrenergic innervation on the extracellular steady-state concentration gradient for 3H-noradrenaline [Elektronische Daten] [E. Schömig, I. Azevedo, D. Moura, U. Trendelenburg] Summary: After inhibition of extraneuronal uptake by corticosterone, isolated right atria and lengthwise halved vasa deferentia of the rat were incubated with 0.2 μmol/l 3H-noradrenaline for 60 min, washed out for 100 min and then prepared for autoradiography. The autoradiographic images were digitized, and silver grain density was determined as a function of the distance from the surface. Silver grain density declined towards the centre of the tissue; the decline was monophasic exponential and significantly steeper in the vas deferens (0.016 μm−1) than in the less densely innervated right atrium (0.011 μm−1). Silver grain density at the surface of the tissue was higher in vas deferens than in right atrium. The results show that the extracellular steady-state concentration gradient for 3H-noradrenaline (generated by uptake, during the incubation with this amine) largely depends on the density of the adrenergic innervation. Springer-Verlag, 1992 Rat vas deferens nationallicence Rat right atrium nationallicence Uptake1 nationallicence 3H-Noradrenaline nationallicence Autoradiography nationallicence Schömig E. Institut für Pharmakologie und Toxikologie, Universität Würzburg, Versbacher Strasse 9, W-8700, Wurzburg, Federal Republic of Germany aut Azevedo I. Laboratório de Farmacologia, Faculdade de Medicina, P-4200, Porto, Portugal aut Moura D. Laboratório de Farmacologia, Faculdade de Medicina, P-4200, Porto, Portugal aut Trendelenburg U. Institut für Pharmakologie und Toxikologie, Universität Würzburg, Versbacher Strasse 9, W-8700, Wurzburg, Federal Republic of Germany aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/5(1992-05-01), 541-543 0028-1298 345:5<541 1992 345 210 https://doi.org/10.1007/BF00168945 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00168945 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schömig E. Institut für Pharmakologie und Toxikologie, Universität Würzburg, Versbacher Strasse 9, W-8700, Wurzburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Azevedo I. Laboratório de Farmacologia, Faculdade de Medicina, P-4200, Porto, Portugal aut NATIONALLICENCE 700 1- Moura D. Laboratório de Farmacologia, Faculdade de Medicina, P-4200, Porto, Portugal aut NATIONALLICENCE 700 1- Trendelenburg U. Institut für Pharmakologie und Toxikologie, Universität Würzburg, Versbacher Strasse 9, W-8700, Wurzburg, Federal Republic of Germany aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/5(1992-05-01), 541-543 0028-1298 345:5<541 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer