caa a22 4500 469079630 CHVBK 20180323132946.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00168951 doi (NATIONALLICENCE)springer-10.1007/BF00168951 The cardiotonic bipyridine AWD 122-60 inhibits adenosine triphosphate-sensitive potassium channels of mouse skeletal muscle [Elektronische Daten] [R. Bodewei, S. Hehl, B. Neumcke] Summary: The inhibition of ATP-sensitive potassium channels in mouse skeletal muscle by the cardiotonic bipyridine AWD 122-60 was investigated with the patch-clamp technique. In excised patches of the inside-out configuration, internally applied AWD 122-60 (10−6−10−3 mol/1) reversibly reduced the open-probability of single ATP-sensitive potassium channels. The agent shortened the periods of channel activity but did not affect the channel conductance. At positive membrane potentials channel inhibition by AWD 122-60 was more pronounced than at negative potentials, the drug concentrations producing 50% channel inhibition were 11 μmol/l at + 40 mV and 29 μmol/l at −40 mV. The Hill coefficients of the concentration-response curves were in the range between 0.5 and 0.6 for both potentials. milrinone (10−4 mol/I), had no effects on ATP-sensitive potassium channels in skeletal muscle. potassium channels in heart muscle by AWD 122-60 are discussed. Springer-Verlag, 1992 Patch clamp nationallicence Adenosine triphosphate-sensitive potassium channel nationallicence Cardiotonic agent nationallicence Skeletal muscle nationallicence Bodewei R. I. Physiologisches Institut der Universität des Saarlandes, W-6650 Homburg/Saar, Federal Republic of Germany aut Hehl S. I. Physiologisches Institut der Universität des Saarlandes, W-6650 Homburg/Saar, Federal Republic of Germany aut Neumcke B. I. Physiologisches Institut der Universität des Saarlandes, W-6650 Homburg/Saar, Federal Republic of Germany aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/5(1992-05-01), 570-577 0028-1298 345:5<570 1992 345 210 https://doi.org/10.1007/BF00168951 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00168951 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bodewei R. I. Physiologisches Institut der Universität des Saarlandes, W-6650 Homburg/Saar, Federal Republic of Germany aut NATIONALLICENCE 700 1- Hehl S. I. Physiologisches Institut der Universität des Saarlandes, W-6650 Homburg/Saar, Federal Republic of Germany aut NATIONALLICENCE 700 1- Neumcke B. I. Physiologisches Institut der Universität des Saarlandes, W-6650 Homburg/Saar, Federal Republic of Germany aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/5(1992-05-01), 570-577 0028-1298 345:5<570 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer