caa a22 4500 469079762 CHVBK 20180323132946.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00165738 doi (NATIONALLICENCE)springer-10.1007/BF00165738 Direct mechanomyographic measurement of the myorelaxant action of baclofen and diazepam in normal and reserpinized rats [Elektronische Daten] [Stanisŀaw Wolfarth, Wacŀaw Kolasiewicz, Krystyna Ossowska, Mirosŀaw Bober] Summary: A pathologically increased muscle tone is frequently observed. Objective methods for measuring directly the muscle-relaxant action of drugs in laboratory animals are scarce. This study shows that a computerized mechanomyographic method allows the assessment of myorelaxant drugs. The method consists of the successive bending and straightening of the rat's foot in the ankle joint and the separate measurement of resistance of extensors and flexors of the hind foot to passive movements. The two well-known antispastic drugs diazepam and baclofen reduced the normal muscle tone in both groups of muscles in non-treated animals as well as the muscle tone increased by reserpine (10 mg/kg i.p.). The results obtained show that the mechanomyographic method directly and reliably reveals the myorelaxant action of drugs. Springer-Verlag, 1992 Muscle tone nationallicence Myorelaxants nationallicence Reserpine nationallicence Diazepam nationallicence Baclofen nationallicence Wolfarth Stanisŀaw Department of Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., PL-31-343, Kraków, Poland aut Kolasiewicz Wacŀaw Department of Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., PL-31-343, Kraków, Poland aut Ossowska Krystyna Department of Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., PL-31-343, Kraków, Poland aut Bober Mirosŀaw Department of Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., PL-31-343, Kraków, Poland aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/2(1992-02-01), 209-212 0028-1298 345:2<209 1992 345 210 https://doi.org/10.1007/BF00165738 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00165738 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wolfarth Stanisŀaw Department of Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., PL-31-343, Kraków, Poland aut NATIONALLICENCE 700 1- Kolasiewicz Wacŀaw Department of Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., PL-31-343, Kraków, Poland aut NATIONALLICENCE 700 1- Ossowska Krystyna Department of Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., PL-31-343, Kraków, Poland aut NATIONALLICENCE 700 1- Bober Mirosŀaw Department of Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St., PL-31-343, Kraków, Poland aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/2(1992-02-01), 209-212 0028-1298 345:2<209 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer