caa a22 4500 469079789 CHVBK 20180323132946.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00165737 doi (NATIONALLICENCE)springer-10.1007/BF00165737 Involvement of µ-opioid receptors in the antitussive effects of pentazocine [Elektronische Daten] [Junzo Kamei, Kiyotaka Katsuma, Yutaka Kasuya] Summary: The effect of pentazocine on the capsaicininduced cough reflex in rats was investigated. Intraperitoneal injection of pentazocine, in doses from 1 to 10 mg/kg, significantly decreased the number of coughs in a dose-dependent manner. The antitussive effect of pentazocine (10 mg/kg, i.p.) was significantly reduced by prior injection of naloxone (0.3 mg/kg, i.p.), but it was unaffected by Mr-2266 BS (5 mg/kg, i.p.), an antagonist of κ-opioid receptors. The antinociceptive potency of pentazocine (30 mg/kg, i.p.), as determined by the formalin test, was significantly reduced by pretreatment with Mr-2266 BS (5 mg/kg, i.p.), whereas naloxane (0.3 mg/ kg, i.p.) had no significant effect on the antinociceptive effect of pentazocine. The antitussive effects of pentazocine (3 mg/kg) and morphine (0.1 mg/kg) were significantly enhanced in rats treated chronically with naloxone (5 mg/kg/day, 5 days), whereas the antitussive effect of U-50,488 H (1 mg/kg, i.p.), a selective κ-opioid agonist, was not enhanced in these rats. By contrast, the antinociceptive effect of morphine (0.01 mg/kg, i.p.) was significantly enhanced in rats that had been pretreated chronically with naloxone. However, the antinociceptive effects induced by pentazocine (3 mg/kg, i.p.) and U-50,488 H (1 mg/kg, i.p.) were unchanged. These results suggest that pentazocine-induced antitussive effects in rats are mediated via stimulation of µ-opioid receptors. Springer-Verlag, 1992 Pentazocine nationallicence Antitussive effect nationallicence Cough reflex nationallicence Analgesia nationallicence Rat nationallicence Kamei Junzo Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, 142, Shinagawa-ku, Tokyo, Japan aut Katsuma Kiyotaka Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, 142, Shinagawa-ku, Tokyo, Japan aut Kasuya Yutaka Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, 142, Shinagawa-ku, Tokyo, Japan aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/2(1992-02-01), 203-208 0028-1298 345:2<203 1992 345 210 https://doi.org/10.1007/BF00165737 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00165737 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kamei Junzo Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, 142, Shinagawa-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Katsuma Kiyotaka Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, 142, Shinagawa-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Kasuya Yutaka Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, 142, Shinagawa-ku, Tokyo, Japan aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/2(1992-02-01), 203-208 0028-1298 345:2<203 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer