caa a22 4500 469079819 CHVBK 20180323132946.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00165732 doi (NATIONALLICENCE)springer-10.1007/BF00165732 Evidence for verapamil-induced functional inhibition of noradrenergic neurotransmission in vivo [Elektronische Daten] [S. Gurtu, S. Seth, A. Roychoudhary] Summary: Contractions of the cat nictitating membrane have been used to explore the effects of calcium channel blockers on neurotransmission in vivo, by comparing the effects of verapamil and nifedipine on contractions of nictitating membrane following either electrical stimulation of the superior cervical ganglion or intravenous injection of the α-adrenoceptor agonist phenylephrine. Verapamil (0.3, 0.6 and 1.2 mg/kg, iv) produced a dose related and reversible inhibition of stimulation induced contractions but did not affect phenylephrine responses of nictitating membrane. Intravenous nifedipine (10, 20 and 40 μg/kg) produced inconsistent effects on both stimulation- and phenylephrine-induced contractions of the nictitating membrane. Thus only verapamil appears to selectively affect noradrenergic neurotransmission in this model, possibly by altering the neurotransmitter release from the terminals innervating the nictitating membrane in the cat. Springer-Verlag, 1992 Verapamil nationallicence Nifedipine nationallicence Calcium channel blockers nationallicence Neurotransmission nationallicence Pre-synaptic effects nationallicence Gurtu S. Department of Pharmacology and Therapeutics, King George's Medical College, 226003, Lucknow, India aut Seth S. Department of Pharmacology and Therapeutics, King George's Medical College, 226003, Lucknow, India aut Roychoudhary A. Department of Pharmacology and Therapeutics, King George's Medical College, 226003, Lucknow, India aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/2(1992-02-01), 172-175 0028-1298 345:2<172 1992 345 210 https://doi.org/10.1007/BF00165732 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00165732 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gurtu S. Department of Pharmacology and Therapeutics, King George's Medical College, 226003, Lucknow, India aut NATIONALLICENCE 700 1- Seth S. Department of Pharmacology and Therapeutics, King George's Medical College, 226003, Lucknow, India aut NATIONALLICENCE 700 1- Roychoudhary A. Department of Pharmacology and Therapeutics, King George's Medical College, 226003, Lucknow, India aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/2(1992-02-01), 172-175 0028-1298 345:2<172 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer