caa a22 4500 469079894 CHVBK 20180323132947.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00165733 doi (NATIONALLICENCE)springer-10.1007/BF00165733 Blood pressure changes modify the release rates of catecholamines in the intermediate nucleus of the solitary tract [Elektronische Daten] [N. Singewald, A. Klausmair, A. Philippu] Summary: In anaesthetized cats, the intermediate aspect of the nucleus of the solitary tract (NTS) was bilaterally superfused with artificial CSF through push-pull cannulae. The release of the endogenous catecholamines dopamine, noradrenaline and adrenaline was determined in the superfusates radioenzymatically. Blood pressure changes were elicited by intravenous injections of drugs (noradrenaline or chlorisondamine), or electrical stimulation of the intermediate NTS with the tip of the push-pull cannula. Intravenous injections of noradrenaline (3 or 10 μg/kg) elicited a rise in the arterial blood pressure which was associated with a decrease in the release rate of adrenaline in the intermediate NTS. The release rates of dopamine and noradrenaline were not influenced. The intravenous injection of chlorisondamine (3 mg/kg) lowered blood pressure and diminished the release rate of dopamine in the intermediate NTS. The release rate of noradrenaline was not modified by chlorisondamine. Electrical stimulation of the intermediate NTS contralateral to the superfused nucleus increased moderately the arterial blood pressure and decreased the release rate of noradrenaline and dopamine, while the release of adrenaline was not influenced. The findings suggest that experimentally induced changes in the arterial blood pressure by drugs injected intravenously modify the release rates of adrenaline and dopamine in the intermediate NTS so as to counteract the blood pressure change. In the intermediate NTS, release of adrenaline from adrenergic nerve terminals seems to act hypertensive. The results obtained with chlorisondamine point to a hypotensive function of endogenous dopamine in the intermediate NTS. Springer-Verlag, 1992 Blood pressure nationallicence Catecholamine release nationallicence Intermediate nucleus of the solitary tract (NTS) nationallicence Push-pull cannula nationallicence Noradrenaline nationallicence Chlorisondamine nationallicence Electrical stimulation nationallicence Singewald N. Institut für Pharmakodynamik und Toxikologie der Universität Innsbruck, Peter-Mayr-Strasse 1, A-6020, Innsbruck, Austria aut Klausmair A. Institut für Pharmakodynamik und Toxikologie der Universität Innsbruck, Peter-Mayr-Strasse 1, A-6020, Innsbruck, Austria aut Philippu A. Institut für Pharmakodynamik und Toxikologie der Universität Innsbruck, Peter-Mayr-Strasse 1, A-6020, Innsbruck, Austria aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/2(1992-02-01), 176-180 0028-1298 345:2<176 1992 345 210 https://doi.org/10.1007/BF00165733 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00165733 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Singewald N. Institut für Pharmakodynamik und Toxikologie der Universität Innsbruck, Peter-Mayr-Strasse 1, A-6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Klausmair A. Institut für Pharmakodynamik und Toxikologie der Universität Innsbruck, Peter-Mayr-Strasse 1, A-6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Philippu A. Institut für Pharmakodynamik und Toxikologie der Universität Innsbruck, Peter-Mayr-Strasse 1, A-6020, Innsbruck, Austria aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/2(1992-02-01), 176-180 0028-1298 345:2<176 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer