caa a22 4500 469079908 CHVBK 20180323132947.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00165740 doi (NATIONALLICENCE)springer-10.1007/BF00165740 Ethanol attenuates the response of locus coeruleus neurons to excitatory amino acid agonists in vivo [Elektronische Daten] [Göran Engberg, Mihály Hajós] Summary: Recent in vitro electrophysiological studies have revealed that ethanol specifically reduces N-methyl-D-aspartate (NMDA)-activated ion currents, e.g. in hippocampal slices. In the present study, utilizing extracellular recording techniques, the effect of ethanol on excitatory amino acid induced excitability of rat locus coeruleus noradrenergic neurons was investigated in vivo. Administration of ethanol (2 g/kg, i.p.) significantly inhibited the excitation of the locus coeruleus neurons as produced by microiontophoretic application of glutamate, NMDA or quisqualate, but not that of kainate. In contrast, the locus coeruleus response to similarly applied acetylcholine was unaffected by the ethanol treatment. Although ethanol did not alter the basal firing rate of locus coeruleus neurons, the drug significantly changed the firing pattern of the neurons into a more regularized rhythm. It is proposed that the presently observed attenuation of glutamate excitation of locus coeruleus by ethanol may constitute part of the underlaying mechanism for ethanol intoxication in man. Springer-Verlag, 1992 Locus coeruleus nationallicence Noradrenaline nationallicence Ethanol nationallicence Glutamate nationallicence Acetylcholine nationallicence NMDA nationallicence Kainate nationallicence Quisqualate nationallicence Engberg Göran Department of Pharmacology, University of Göteborg, P.O. Box 33031, S-40033, Göteborg, Sweden aut Hajós Mihály Department of Physiology, A. Szent-Györgyi Medical University, Szeged, Hungary aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/2(1992-02-01), 222-226 0028-1298 345:2<222 1992 345 210 https://doi.org/10.1007/BF00165740 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00165740 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Engberg Göran Department of Pharmacology, University of Göteborg, P.O. Box 33031, S-40033, Göteborg, Sweden aut NATIONALLICENCE 700 1- Hajós Mihály Department of Physiology, A. Szent-Györgyi Medical University, Szeged, Hungary aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/2(1992-02-01), 222-226 0028-1298 345:2<222 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer