caa a22 4500 469079916 CHVBK 20180323132947.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00165729 doi (NATIONALLICENCE)springer-10.1007/BF00165729 The effect of intrastriatal application of directly and indirectly acting dopamine agonists and antagonists on the in vivo release of acetylcholine measured by brain microdialysis [Elektronische Daten] The importance of the post-surgery interval [P. De Boer, G. Damsma, Q. Schram, J. Stoof, J. Zaagsma, B. Westerink] Summary: The effect of intrastriatal application of D-1, D-2 and indirect dopaminergic drugs on the release of striatal acetylcholine as a function of the post-implantation intervals was studied using in vivo microdialysis. The dopamine, D-2 agonists LY 171555 and (−)N0437 inhibited the release of striatal acetylcholine to 40% of control values 16-24 h after implantation of the dialysis cannula. When LY 171555 was infused 40-48 h after implantation of the dialysis cannula, the response was attenuated to 20% of control values. Meanwhile, the effectiveness of infusions of the antagonists (−)sulpiride and haloperidol was augmented from a non significant effect at 16-24 h to a 150% increase 40-48 h after implantation of the cannula. Infusions of the dopamine releasing agent amphetamine or the dopamine uptake inhibitor nomifensine resulted in a dose-dependent increase in the overflow of dopamine. Not until a sevenfold increase in the level of dopamine was seen, the release of acetylcholine was significantly affected. This hyporesponsiveness of the striatal cholinergic interneurons to endogenous dopamine could not be attributed to dopamine D-1 receptor activation, since no effects on striatal acetylcholine release were found by intrastriatal infusions of the selective D-1 agonist CY 208-243 or the selective D-1 antagonist SCH 23390. The results indicate that dopamine D-2 receptors are involved in the regulation of striatal acetylcholine release and that these receptors are tonically occupied by endogenous dopamine under the present experimental conditions 40-48 h after probe implantation. The fact that cholinergic responses to intrastriatally applied dopaminergic agents are dynamic with respect to the time between implantation surgery of the dialysis tube and the experimental measurements suggests that the striatal neuronal system is perturbated by the implantation of a dialysis probe for a considerable length of time. Springer-Verlag, 1992 Acetylcholine release nationallicence Dopamine release nationallicence Microdialysis nationallicence Striatum nationallicence D-1 and D-2 dopamine receptors nationallicence Post-implantation interval nationallicence De Boer P. Department of Medicinal Chemistry, University of Groningen, Ant. Deusinglaan 2, NL-9713 AW, Groningen, The Netherlands aut Damsma G. Preclinical Research, Pharma Division, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland aut Schram Q. Department of Medicinal Chemistry, University of Groningen, Ant. Deusinglaan 2, NL-9713 AW, Groningen, The Netherlands aut Stoof J. Department of Neurology, Free University, van den Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands aut Zaagsma J. Department of Pharmacology and Therapeutics, University Centre for Pharmacy, University of Groningen, Ant. Deusinglaan 2, NL-9713 AW, Groningen, The Netherlands aut Westerink B. Department of Medicinal Chemistry, University of Groningen, Ant. Deusinglaan 2, NL-9713 AW, Groningen, The Netherlands aut Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/2(1992-02-01), 144-152 0028-1298 345:2<144 1992 345 210 https://doi.org/10.1007/BF00165729 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00165729 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Boer P. Department of Medicinal Chemistry, University of Groningen, Ant. Deusinglaan 2, NL-9713 AW, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Damsma G. Preclinical Research, Pharma Division, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland aut NATIONALLICENCE 700 1- Schram Q. Department of Medicinal Chemistry, University of Groningen, Ant. Deusinglaan 2, NL-9713 AW, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Stoof J. Department of Neurology, Free University, van den Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Zaagsma J. Department of Pharmacology and Therapeutics, University Centre for Pharmacy, University of Groningen, Ant. Deusinglaan 2, NL-9713 AW, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Westerink B. Department of Medicinal Chemistry, University of Groningen, Ant. Deusinglaan 2, NL-9713 AW, Groningen, The Netherlands aut NATIONALLICENCE 773 0- Naunyn-Schmiedeberg's Archives of Pharmacology Springer-Verlag 345/2(1992-02-01), 144-152 0028-1298 345:2<144 1992 345 210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer