caa a22 4500 46908166X CHVBK 20180323132952.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF00338059 doi (NATIONALLICENCE)springer-10.1007/BF00338059 Distribution and coexistence of chromogranin A-, serotonin-and pancreastatin-like immunoreactivity in endocrine-like cells of the human anal canal [Elektronische Daten] [Dieter Hörsch, Eberhard Weihe, Sabine Müller, Edgar Hancke] Summary: The comparative distribution and coexistence of chromogranin A (CGA)-, serotonin (5-hydroxytryptamine; 5-HT)- and pancreastatin (PST)-like immunoreactivity in endocrine-like cells of the human anal canal was investigated by light-microscopic immunocytochemistry. The largest population of colorectal endocrine-like cells consisted of CGA-immunoreactive (ir) cells, followed by the 5-HT-ir and PST-ir cell population. In the anal transitional zone (ATZ), CGA-and 5-HT-immunoreactivity was equally distributed; ir-PST was confined to a smaller endocrine-like cell population. In the squamous zone and the perianal skin, Merkel cells in the basal layer of the epidermis and hair follicles exhibited ir-CGA and ir-PST but no ir-5-HT. Double immunofluorescence on identical sections revealed distinct coexistence patterns. In the colorectal zone, about 2/3 of the CGA-ir endocrine-like cells also stained for 5-HT, whereas in the ATZ epithelium, CGA- and 5-HT-immunoreactivity completely overlapped. No 5-HT-immunoreactivity could be detected in CGA-ir Merkel cells of the squamous zone of the anal canal and the perianal skin. PST-immunoreactivity was present in about 1/3 of the CGA-ir colorectal and anal transitional endocrine-like cells and in about 1/4 of the Merkel-cell population staining for CGA. These chemically heterogeneous phenotypes of the anal endocrine-like and Merkel cells may reflect a specific regulatory role of these cells in the various epithelial linings of the human anal canal and the perianal skin. Springer-Verlag, 1992 Anal canal nationallicence Diffuse neuroendocrine system nationallicence Gastrointestinal tract nationallicence Chromogranin A nationallicence Serotonin nationallicence Pancreastatin nationallicence Human nationallicence Hörsch Dieter Anatomisches Institut, Histologischer Bereich, Saarstrasse 19-21, W-6500, Mainz, Federal Republic of Germany aut Weihe Eberhard Anatomisches Institut, Histologischer Bereich, Saarstrasse 19-21, W-6500, Mainz, Federal Republic of Germany aut Müller Sabine Anatomisches Institut, Histologischer Bereich, Saarstrasse 19-21, W-6500, Mainz, Federal Republic of Germany aut Hancke Edgar Abteilung für Allgemeine Chirurgie, Johannes Gutenberg-Universität, Saarstrasse 19-21, W-6500, Mainz, Federal Republic of Germany aut Cell and Tissue Research Springer-Verlag 268/1(1992-04-01), 109-116 0302-766X 268:1<109 1992 268 441 https://doi.org/10.1007/BF00338059 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00338059 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hörsch Dieter Anatomisches Institut, Histologischer Bereich, Saarstrasse 19-21, W-6500, Mainz, Federal Republic of Germany aut NATIONALLICENCE 700 1- Weihe Eberhard Anatomisches Institut, Histologischer Bereich, Saarstrasse 19-21, W-6500, Mainz, Federal Republic of Germany aut NATIONALLICENCE 700 1- Müller Sabine Anatomisches Institut, Histologischer Bereich, Saarstrasse 19-21, W-6500, Mainz, Federal Republic of Germany aut NATIONALLICENCE 700 1- Hancke Edgar Abteilung für Allgemeine Chirurgie, Johannes Gutenberg-Universität, Saarstrasse 19-21, W-6500, Mainz, Federal Republic of Germany aut NATIONALLICENCE 773 0- Cell and Tissue Research Springer-Verlag 268/1(1992-04-01), 109-116 0302-766X 268:1<109 1992 268 441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer