caa a22 4500 469081775 CHVBK 20180323132952.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF00338066 doi (NATIONALLICENCE)springer-10.1007/BF00338066 Changes in the extracellular matrix of the normal human breast during the menstrual cycle [Elektronische Daten] [J. Ferguson, A. Schor, A. Howell, M. Ferguson] Summary: The normal human mammary gland undergoes a well defined sequence of histological changes in both epithelial and stromal compartments during the menstrual cycle. Studies in vitro have suggested that the extracellular matrix surrounding the individual cells plays a central role in modulating a wide variety of cellular events, including proliferation, differentiation and gene expression. We therefore investigated the distribution of a number of extracellular matrix molecules in the normal breast during the menstrual cycle. By use of indirect immunofluorescence, with specific antibodies, we demonstrated that laminin, heparan sulphate proteoglycan, type IV collagen, type V collagen, chondroitin sulphate and fibronectin undergo changes in distribution during the menstrual cycle, whereas collagen types I, III, VI and VII remain unchanged. These changes were most marked in the basement membrane, sub-basement membrane zone and delimiting layer of fibroblasts surrounding the ductules where basement membrane markers such as laminin, heparan sulphate proteoglycan, and type IV and V collagens appear greatly reduced during the mid-cycle period (days 8 to 22). These results suggest that some extracellular matrix molecules may act as medittors in the hormonal control of the mammary gland, whereas others may have a predominantly structural role. Springer-Verlag, 1992 Mammary gland nationallicence Extracellular matrix nationallicence Menstrual cycle nationallicence Breast cancer nationallicence Immunohistochemistry nationallicence Epithelial cell behaviour nationallicence Human nationallicence Ferguson J. CRC Department of Medical Oncology and Holt Radium Institute, Christie Hospital, wilmslow Road, M20 9BX, Manchester, UK aut Schor A. CRC Department of Medical Oncology and Holt Radium Institute, Christie Hospital, wilmslow Road, M20 9BX, Manchester, UK aut Howell A. CRC Department of Medical Oncology and Holt Radium Institute, Christie Hospital, wilmslow Road, M20 9BX, Manchester, UK aut Ferguson M. Department of Cell and Structural Biology, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, UK aut Cell and Tissue Research Springer-Verlag 268/1(1992-04-01), 167-177 0302-766X 268:1<167 1992 268 441 https://doi.org/10.1007/BF00338066 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00338066 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ferguson J. CRC Department of Medical Oncology and Holt Radium Institute, Christie Hospital, wilmslow Road, M20 9BX, Manchester, UK aut NATIONALLICENCE 700 1- Schor A. CRC Department of Medical Oncology and Holt Radium Institute, Christie Hospital, wilmslow Road, M20 9BX, Manchester, UK aut NATIONALLICENCE 700 1- Howell A. CRC Department of Medical Oncology and Holt Radium Institute, Christie Hospital, wilmslow Road, M20 9BX, Manchester, UK aut NATIONALLICENCE 700 1- Ferguson M. Department of Cell and Structural Biology, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, UK aut NATIONALLICENCE 773 0- Cell and Tissue Research Springer-Verlag 268/1(1992-04-01), 167-177 0302-766X 268:1<167 1992 268 441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer