caa a22 4500 469081872 CHVBK 20180323132952.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00319158 doi (NATIONALLICENCE)springer-10.1007/BF00319158 Macrophage subpopulations and reticulum cells in rat placenta [Elektronische Daten] An immunohistochemical study [D. van Oostveen, T. van den Berg, J. Damoiseaux, E. van Rees] Summary: The placenta is a unique mixture of histoincompatible cells derived from mother and fetus. The aim of the present study was to obtain information on the development of macrophage subpopulations and reticulum cells during pregnancy in the placenta. Placentas of Wistar rats were removed at several stages of gestation, and were studied by immunohistochemical techniques applying monoclonal antibodies against macrophage subpopulations, lymphoid cells and reticulum cells. The expression of MHC class-II antigens was also studied. Throughout gestation macrophages were demonstrable in large numbers in the endometrium, in the myometrium and in the metrial gland, which is a compartment developing in the myometrium of pregnant rodents. In the labyrinth, a placenta compartment consisting of fetal cells, macrophages (probably of fetal origin) were already found on day 15. In the spongiotrophoblast and decidua basalis, which are layers of the placenta containing both maternal and fetal cells, only a few macrophages were recognized throughout gestation. The monoclonal antibody ED11, raised against reticulum cells, recognized fiber-like structures lining the blood sinuses of the spongiotrophoblast, in which only maternal blood is circulating. As the antigen recognized by ED11 is believed to play a role in the trapping of immune complexes, the spongiotrophoblast may play a role in the protection of the fetus from circulating immune complexes. Springer-Verlag, 1992 Placenta nationallicence Macrophages nationallicence Reticulum cells nationallicence Immunohistochemistry nationallicence Rat (Wistar) nationallicence van Oostveen D. Department of Cell Biology, Division Histology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands aut van den Berg T. Department of Cell Biology, Division Histology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands aut Damoiseaux J. Department of Cell Biology, Division Histology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands aut van Rees E. Department of Cell Biology, Division Histology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands aut Cell and Tissue Research Springer-Verlag 268/3(1992-06-01), 513-519 0302-766X 268:3<513 1992 268 441 https://doi.org/10.1007/BF00319158 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00319158 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Oostveen D. Department of Cell Biology, Division Histology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van den Berg T. Department of Cell Biology, Division Histology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Damoiseaux J. Department of Cell Biology, Division Histology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van Rees E. Department of Cell Biology, Division Histology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Cell and Tissue Research Springer-Verlag 268/3(1992-06-01), 513-519 0302-766X 268:3<513 1992 268 441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer