caa a22 4500 46908197X CHVBK 20180323132953.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00319156 doi (NATIONALLICENCE)springer-10.1007/BF00319156 Plasticity in expression of calcitonin gene-related peptide and substance P immunoreactivity in ganglia and fibres following guanethidine and/or capsaicin denervation [Elektronische Daten] [M. Mione, J. Cavanagh, K. Kirkpatrick, G. Burnstock] Summary: This study was designed to investigate the effects of multiple denervation procedures on calcitonin gene-related peptide- and substance P-immunoreactive neurons in sympathetic and sensory cranial ganglia and in selected targets. Sympathectomy by long-term guanethidine treatment induced a pronounced increase in calcitonin gene-related peptide-immunoreactive and substance P-immunoreactive nerve fibres in all the tissues investigated, in contrast to a significant reduction of immunoreactive cell bodies. Neonatal capasaicin treatment abolished substance P immunoreactivity in many targets and caused a dramatic reduction of substance P-immunoreactive sensory nerve cell bodies; calcitonin gene-related peptide-immunoreactive nerve density was decreased, but the number of immunoreactive nerve cell bodies was unchanged. Guanethidine treatment of capsaicin-injected rats reversed the loss of calcitonin gene-related peptide-immunoreactive nerves, but not that of substance P-immunoreactive neurons. In the iris, capsaicin treatment had little effect on calcitonin gene-related peptide- and substance P-immunoreactive nerves, suggesting that in rats the majority of these fibres originate from capsaicin-insensitive neurons. The results suggest that the denervation procedures used in this study alter the synthesis and transport of neuropeptides in sensory neurons in conjunction with changes in the number of nerve fibres. Springer-Verlag, 1992 Sympathetic ganglia nationallicence Sensory ganglia nationallicence Denervation nationallicence Guanethidine nationallicence Capsaicin nationallicence Image analysis nationallicence Rat (Wistar) nationallicence Mione M. Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK aut Cavanagh J. Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK aut Kirkpatrick K. Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK aut Burnstock G. Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK aut Cell and Tissue Research Springer-Verlag 268/3(1992-06-01), 491-504 0302-766X 268:3<491 1992 268 441 https://doi.org/10.1007/BF00319156 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00319156 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mione M. Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 700 1- Cavanagh J. Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 700 1- Kirkpatrick K. Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 700 1- Burnstock G. Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 773 0- Cell and Tissue Research Springer-Verlag 268/3(1992-06-01), 491-504 0302-766X 268:3<491 1992 268 441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer