caa a22 4500 469082097 CHVBK 20180323132953.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00318794 doi (NATIONALLICENCE)springer-10.1007/BF00318794 Structural changes in condylar cartilage following prolonged exposure to the human parathyroid hormone fragment (hPTH) 1-34 in vitro [Elektronische Daten] [D. Lewinson, R. Shurtz-Swirski, P. Schenzer, E. Wingender, H. Mayer, M. Silbermann] Summary: This investigation presents the structural changes in condylar cartilage incubated in the presence of human parathyroid hormone (1-34) in an organ culture system for 6 to 12 days. Control cultures maintained their cartilaginous characteristics whereas human parathyroid hormone (1-34)-treated cultures revealed the following modifications: (1) The chondroprogenitor cell zone at the apical region of the explant underwent a substantial enlargement. The cells changed from a mesenchyme-like morphology into polygonal, glycogen-rich cells that were tightly attached to each other by a fibrillar intercellular matrix, but even by 12 days the apical region was comprised of healthy cells. (2) The mineralizing zone in the hypertrophic cartilage revealed a change in its cellular population. Hypertrophic chondrocytes were replaced by cells with amoeboid extensions and large numbers of secretory granules or vesicles. Based upon the above findings it appears that the condroprogenitor cells that are initially stimulated to proliferate, are being suppressed from subsequent differentiation into chondroblasts; and that hypertrophic chondrocytes apparently undergo a dedifferentiation process followed by development into an as yet unknown cell population. Springer-Verlag, 1992 Parathyroid hormone nationallicence Cartilage nationallicence Chondrocytes nationallicence Joints nationallicence Organ culture nationallicence Mouse (ICR) nationallicence Lewinson D. Laboratory for Musculoskeletal Research, The Rappaport Family Institute for Research in the Medical Sciences and the Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, 31096, Haifa, Israel aut Shurtz-Swirski R. Laboratory for Musculoskeletal Research, The Rappaport Family Institute for Research in the Medical Sciences and the Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, 31096, Haifa, Israel aut Schenzer P. Laboratory for Musculoskeletal Research, The Rappaport Family Institute for Research in the Medical Sciences and the Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, 31096, Haifa, Israel aut Wingender E. Institut für Genetik, G.B.F., W-3300, Braunschweig, Germany aut Mayer H. Institut für Genetik, G.B.F., W-3300, Braunschweig, Germany aut Silbermann M. Laboratory for Musculoskeletal Research, The Rappaport Family Institute for Research in the Medical Sciences and the Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, 31096, Haifa, Israel aut Cell and Tissue Research Springer-Verlag 268/2(1992-05-01), 257-266 0302-766X 268:2<257 1992 268 441 https://doi.org/10.1007/BF00318794 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00318794 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lewinson D. Laboratory for Musculoskeletal Research, The Rappaport Family Institute for Research in the Medical Sciences and the Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, 31096, Haifa, Israel aut NATIONALLICENCE 700 1- Shurtz-Swirski R. Laboratory for Musculoskeletal Research, The Rappaport Family Institute for Research in the Medical Sciences and the Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, 31096, Haifa, Israel aut NATIONALLICENCE 700 1- Schenzer P. Laboratory for Musculoskeletal Research, The Rappaport Family Institute for Research in the Medical Sciences and the Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, 31096, Haifa, Israel aut NATIONALLICENCE 700 1- Wingender E. Institut für Genetik, G.B.F., W-3300, Braunschweig, Germany aut NATIONALLICENCE 700 1- Mayer H. Institut für Genetik, G.B.F., W-3300, Braunschweig, Germany aut NATIONALLICENCE 700 1- Silbermann M. Laboratory for Musculoskeletal Research, The Rappaport Family Institute for Research in the Medical Sciences and the Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, 31096, Haifa, Israel aut NATIONALLICENCE 773 0- Cell and Tissue Research Springer-Verlag 268/2(1992-05-01), 257-266 0302-766X 268:2<257 1992 268 441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer