caa a22 4500 469082364 CHVBK 20180323132954.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF00318686 doi (NATIONALLICENCE)springer-10.1007/BF00318686 Confocal microscopic and other observations on the distal end of the thick limb of the human loop of Henle [Elektronische Daten] [Alexander Howie, Gerald Johnson] Summary: Various antibodies and lectins were used in a histological study of the human renal tubule, particularly of the distal end of the thick limb of the loop of Henle. The thick limb, identified by antibody to Tamm-Horsfall protein, ended abruptly, either at the macula densa or at a variable distance after it. At this point there was an abrupt change in cell size. Confocal microscopy and other techniques showed that this point marked an abrupt beginning of tubular staining by the cytokeratin antibody PKK 2 and the lectin UEA 1, with an abrupt end of staining by the lectin DBA. Distal from this point, there were gradual changes in staining of the tubule by various reagents including other antibodies to cytokeratins. These structural findings suggest that there is a fundamental change in the tubule at the end of the thick limb. The abrupt end to the thick limb in man resembles that seen in the rat and the rabbit. Springer-Verlag, 1992 Kidney nationallicence Distal tubule nationallicence Tamm-Horsfall protein nationallicence Cytokeratin nationallicence Immunohistochemistry nationallicence Human nationallicence Howie Alexander Department of Pathology and Immunology, University of Birmingham, B15 2TT, Birmingham, UK aut Johnson Gerald Department of Pathology and Immunology, University of Birmingham, B15 2TT, Birmingham, UK aut Cell and Tissue Research Springer-Verlag 267/1(1992-01-01), 11-16 0302-766X 267:1<11 1992 267 441 https://doi.org/10.1007/BF00318686 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00318686 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Howie Alexander Department of Pathology and Immunology, University of Birmingham, B15 2TT, Birmingham, UK aut NATIONALLICENCE 700 1- Johnson Gerald Department of Pathology and Immunology, University of Birmingham, B15 2TT, Birmingham, UK aut NATIONALLICENCE 773 0- Cell and Tissue Research Springer-Verlag 267/1(1992-01-01), 11-16 0302-766X 267:1<11 1992 267 441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer