caa a22 4500 469082585 CHVBK 20180323132954.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00319371 doi (NATIONALLICENCE)springer-10.1007/BF00319371 Immunocytochemical demonstration of rod-opsin, S-antigen, and neuron-specific proteins in the human pineal gland [Elektronische Daten] [Shi-Kai Huang, David Klein, Horst-W. Korf] Summary: The aim of this study was to examine whether rod-opsin and S-antigen immunoreactions were present in the pineal organ of adult man and how these immunoreactions were correlated with neuronal markers, e.g., synaptophysin, and neurofilaments L, H and M. Three perfusion-fixed epithalamic regions including the pineal organ and five pineal glands obtained at routine autopsy were used. The specimens were taken from female or male patients, 25 to 85 years of age. All immunoreactions were performed using highly specific, well-characterized antibodies. Rod-opsin and S-antigen-immunoreactive pinealocytes occurred in all pineal organs investigated; however, the immunoreaction was restricted to small subpopulations of pinealocytes (rod-opsin immunoreaction: approximately 3%-5%; S-antigen immunoreaction: approximately 5%-10% of the total population). In contrast, immunoreactions for synaptophysin and neurofilaments M and H were present in numerous pinealocytes. Immunoreactivity for neurofilament L was not found. These data suggest that the cellular composition of the human pineal organ is heterogeneous. Moreover, the presence of rod-opsin and S-antigen immunoreactions in the human pineal organ indicates that it may be affected by autoimmune retinal diseases that are provoked by antibodies against these proteins, as is the case in rodents and non-human primates. Springer-Verlag, 1992 Pinealocytes nationallicence Rod-opsin nationallicence Retinal S-antigen nationallicence Synaptophysin nationallicence Neurofilaments nationallicence Human nationallicence Huang Shi-Kai Institut für Anatomie und Zytobiologie, Justus-Liebig-Universität, W-6300, Giessen, Federal Republic of Germany aut Klein David Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, 20892, Bethesda, MD, USA aut Korf Horst-W Zentrum der Morphologie, Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, W-6000, Frankfurt/Main 70, Federal Republic of Germany aut Cell and Tissue Research Springer-Verlag 267/3(1992-03-01), 493-498 0302-766X 267:3<493 1992 267 441 https://doi.org/10.1007/BF00319371 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00319371 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huang Shi-Kai Institut für Anatomie und Zytobiologie, Justus-Liebig-Universität, W-6300, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Klein David Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Korf Horst-W Zentrum der Morphologie, Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, W-6000, Frankfurt/Main 70, Federal Republic of Germany aut NATIONALLICENCE 773 0- Cell and Tissue Research Springer-Verlag 267/3(1992-03-01), 493-498 0302-766X 267:3<493 1992 267 441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer