caa a22 4500 469082720 CHVBK 20180323132955.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00302970 doi (NATIONALLICENCE)springer-10.1007/BF00302970 Postnatal development of von Ebner's glands: accumulation of a protein of the lipocalin superfamily in taste papillae of rat tongue [Elektronische Daten] [Kai Kock, Michael Bläker, Hartwig Schmale] Summary: Antibodies produced against rat von Ebner's gland (VEG) protein, a recently characterized member of a lipophilic ligand carrier protein family, detect this protein immunocytochemically in von Ebner's gland acini and show that it is present at high concentrations in the clefts of circumvallate and foliate papillae. During embryonic development, von Ebner's gland anlagen are innervated (as shown immunocytochemically using neuronal specific antibodies) as early as embryonic day 20, before lateral glandular outgrowth and VEG protein can be observed. Expression of the VEG protein as determined by in sity hybridization and immunocytochemistry begins at postnatal day-2 cells in differentiating and branching off from von Ebner's gland ducts, and sharply increases with further enlargement and maturation of the gland. The close temporal correlation of von Ebner's gland innervation and VEG protein expression with papilla innervation and taste-bud development suggests a functional relationship of both structures. VEG protein might control access of lipophilic sapid molecules, such as bitter substances, to the gustatory receptors. Springer-Verlag, 1992 Salivary glands nationallicence Carrier proteins nationallicence Lipocalins nationallicence Papillae, lingual nationallicence Perireceptor event nationallicence Rat (Wistar) nationallicence Kock Kai Institut für Zellbiochemie und klinische Neurobiologie, Universität Hamburg, Martinistrasse 52, W-2000, Hamburg 20, Germany aut Bläker Michael Institut für Zellbiochemie und klinische Neurobiologie, Universität Hamburg, Martinistrasse 52, W-2000, Hamburg 20, Germany aut Schmale Hartwig Institut für Zellbiochemie und klinische Neurobiologie, Universität Hamburg, Martinistrasse 52, W-2000, Hamburg 20, Germany aut Cell and Tissue Research Springer-Verlag 267/2(1992-02-01), 313-320 0302-766X 267:2<313 1992 267 441 https://doi.org/10.1007/BF00302970 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00302970 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kock Kai Institut für Zellbiochemie und klinische Neurobiologie, Universität Hamburg, Martinistrasse 52, W-2000, Hamburg 20, Germany aut NATIONALLICENCE 700 1- Bläker Michael Institut für Zellbiochemie und klinische Neurobiologie, Universität Hamburg, Martinistrasse 52, W-2000, Hamburg 20, Germany aut NATIONALLICENCE 700 1- Schmale Hartwig Institut für Zellbiochemie und klinische Neurobiologie, Universität Hamburg, Martinistrasse 52, W-2000, Hamburg 20, Germany aut NATIONALLICENCE 773 0- Cell and Tissue Research Springer-Verlag 267/2(1992-02-01), 313-320 0302-766X 267:2<313 1992 267 441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer