caa a22 4500 469082844 CHVBK 20180323132955.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00302975 doi (NATIONALLICENCE)springer-10.1007/BF00302975 Localization of binding sites for atrial natriuretic factor and angiotensin II in the central nervous system of the clawed toad Xenopus laevis [Elektronische Daten] [Werner Kloas, Wilfried Hanke] Summary: The distribution of binding sites for atrial natriuretic factor (ANF) and angiotensin II (A II) was investigated in the central nervous system (CNS) of the clawed toad Xenopus laevis by means of in vitro autoradiography using [125I]-rat ANF(99-126) or [125I] [Val5] A II and [125I]human A II as labeled ligands. The highest densities of specific ANF-binding were detected in the nucleus habenularis, thalamic regions, hypophyseal pars nervosa and nucleus interpeduncularis. Moderate ANF-binding was found in the bulbus olfactorius, pallium, septum, striatum, lateral forebrain bundle, nucleus infundibularis, hypophyseal pars distalis and tectum. The highest levels of specific A II binding sites were observed in the nucleus praeopticus, nucleus habenularis, hypophyseal pars nervosa and pars distalis, whereas the amygdala contained moderate A II binding. The existence of specific binding sites for ANF and A II in the CNS of Xenopus laevis suggests that both peptides act as neurotransmitters or neuromodulators in the amphibian CNS. The co-localization of dense binding sites for both peptides in the nucleus habenularis, hypophyseal pars nervosa and pars distalis supports the view that ANF and A II have opposite regulatory functions in these regions. Springer-Verlag, 1992 Central nervous system nationallicence Atrial natriuretic factor nationallicence Angiotensin II nationallicence In vitro autoradiography nationallicence Receptors, binding sites nationallicence Xenopus laevis (Anura) nationallicence Kloas Werner Zoologisches Institut II des Universität, Kaiserstrasse 12, W-7500, Karlsruhe 1, Germany aut Hanke Wilfried Zoologisches Institut II des Universität, Kaiserstrasse 12, W-7500, Karlsruhe 1, Germany aut Cell and Tissue Research Springer-Verlag 267/2(1992-02-01), 365-373 0302-766X 267:2<365 1992 267 441 https://doi.org/10.1007/BF00302975 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00302975 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kloas Werner Zoologisches Institut II des Universität, Kaiserstrasse 12, W-7500, Karlsruhe 1, Germany aut NATIONALLICENCE 700 1- Hanke Wilfried Zoologisches Institut II des Universität, Kaiserstrasse 12, W-7500, Karlsruhe 1, Germany aut NATIONALLICENCE 773 0- Cell and Tissue Research Springer-Verlag 267/2(1992-02-01), 365-373 0302-766X 267:2<365 1992 267 441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer