caa a22 4500 469083050 CHVBK 20180323132956.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF00381884 doi (NATIONALLICENCE)springer-10.1007/BF00381884 A blood-brain barrier without tight junctions in the fly central nervous system in the early postembryonic stage [Elektronische Daten] [Jyh-Lyh Juang, Stanley Carlson] Summary: The anatomical basis of the vertebrate blood-brain barrier is a series of tight junctions between endothelial cells of capillaries in the central nervous system. Over two decades ago, tight junctions were also proposed as the basis of the blood-brain barrier in insects. Currently there is a growing understanding that septate junctions might possess barrier properties in various invertebrate epithelial cells. We now examine these two views by studying the blood-brain barrier properties of the early postembryonic larva of a dipteran fly (Delia platura) by transmission electron microscopy. Newly hatched larvae possess a functioning blood-brain barrier that excludes the extracellular tracer, ionic lanthanum. This barrier is intact throughout the second instar stage as well. The ultrastructural correlate of this barrier is a series of extensive septate junctions that pervade the intercellular space between adjacent perineurial cells. No tight junctions were located in either nerve, glial or perineurial cell layers. We suggest that the overall barrier might involve septate junctions within extensive, meandering intercellular clefts. Springer-Verlag, 1992 Blood-brain barrier nationallicence Central nervous system nationallicence Septate junction nationallicence Tight junction nationallicence Lanthanum nationallicence Glial cell nationallicence Maggot nationallicence Delia platura (Insecta) nationallicence Juang Jyh-Lyh Department of Entomology, Neuroscience Training Program, University of Wisconsin, 53706, Madison, WI, USA aut Carlson Stanley Department of Entomology, Neuroscience Training Program, University of Wisconsin, 53706, Madison, WI, USA aut Cell and Tissue Research Springer-Verlag 270/1(1992-10-01), 95-103 0302-766X 270:1<95 1992 270 441 https://doi.org/10.1007/BF00381884 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00381884 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Juang Jyh-Lyh Department of Entomology, Neuroscience Training Program, University of Wisconsin, 53706, Madison, WI, USA aut NATIONALLICENCE 700 1- Carlson Stanley Department of Entomology, Neuroscience Training Program, University of Wisconsin, 53706, Madison, WI, USA aut NATIONALLICENCE 773 0- Cell and Tissue Research Springer-Verlag 270/1(1992-10-01), 95-103 0302-766X 270:1<95 1992 270 441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer