caa a22 4500 469083379 CHVBK 20180323132957.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF00645043 doi (NATIONALLICENCE)springer-10.1007/BF00645043 The distribution of type-2 chain histo-blood group antigens in normal cycling human endometrium [Elektronische Daten] [Vibeke Ravn, Christence Teglbjærg, Ulla Mandel, Erik Dabelsteen] Summary: The blood group ABO(H) determinants are major allogenic antigens in both erythrocytes and tissue of man. These antigens and related carbohydrates are markers of cellular maturation and differentiation in many epithelial tissues and have recently attracted great interest as tumor-associated antigens. Previous studies of endometrial tissues have indicated that glycosylation in this tissue may be related to hormonal stimulation. We have investigated the immunohistochemical distribution of type-2 chain histo-blood group-related carbohydrates in specimens of normal, cycling endometria obtained from hysterectomies on women with known ABO/Lewis erythrocyte type and saliva secretor status. N-acetyllactosamine and Lex were demonstrated to be uninfluenced by the genetic background. A and Aley antigens were exclusively demonstrated in endometria from blood group A individuals, while Ley was expressed in endometria from blood group 0 individuals mainly. The precursor N-acetyllactosamine as well as the terminal H, A, and ALey antigens were shown in only a few cells. In contrast, N-acetyllactosamine substituted by sialic acid and/or fucose residues (Lex, sialosyl-Lex, Ley) were demonstrated in epithelial cells of normal, cycling endometrium, but with both quantitative and qualitative differences in staining relating to the menstrual cycle, indicating that type-2 chain antigens are expressed under both genetic and hormonal influence in human cycling endometrium. Springer-Verlag, 1992 Human cycling endometrium nationallicence Type-2 chain ABO antigens nationallicence Immunohistochemistry nationallicence Genetic and hormonal regulation nationallicence Genetic regulation nationallicence Hormonal regulation nationallicence Human nationallicence Ravn Vibeke Department of Pathology, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100, Copenhagen, Denmark aut Teglbjærg Christence Department of Pathology, Herlev Hospital, University of Copenhagen, Denmark aut Mandel Ulla Department of Oral Diagnostics, School of Dentistry, University of Copenhagen, Denmark aut Dabelsteen Erik Department of Oral Diagnostics, School of Dentistry, University of Copenhagen, Denmark aut Cell and Tissue Research Springer-Verlag 270/3(1992-12-01), 425-433 0302-766X 270:3<425 1992 270 441 https://doi.org/10.1007/BF00645043 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00645043 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ravn Vibeke Department of Pathology, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Teglbjærg Christence Department of Pathology, Herlev Hospital, University of Copenhagen, Denmark aut NATIONALLICENCE 700 1- Mandel Ulla Department of Oral Diagnostics, School of Dentistry, University of Copenhagen, Denmark aut NATIONALLICENCE 700 1- Dabelsteen Erik Department of Oral Diagnostics, School of Dentistry, University of Copenhagen, Denmark aut NATIONALLICENCE 773 0- Cell and Tissue Research Springer-Verlag 270/3(1992-12-01), 425-433 0302-766X 270:3<425 1992 270 441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer