caa a22 4500 469083727 CHVBK 20180323132958.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00384734 doi (NATIONALLICENCE)springer-10.1007/BF00384734 Organization of cells and extracelluar matrix in mesenteric arteries of spontaneously hypertensive rats [Elektronische Daten] [H. Walker-Caprioglio, J. Trotter, S. Little, L. McGuffee] Summary: Biochemical studies have been used to assess the quantitative changes in elastin and collagen in hypertensive vs. normotensive arteries. However, the relative distribution and organization of these fibrous proteins is likely to be equal in importance to their absolute amounts. In this study we have used scanning electron microscopy in association with selective digestion techniques to assess the organization of cellular and extracellular components of the tunica media of mesenteric arteries of spontaneously hypertensive rats. Superior and small mesenteric arteries were digested with acid, alkali, or bleach to exposure cells, collagen, or collagen and elastin, respectively. We observed that hypertension does not cause a qualitative change in the 3-dimensional arrangement of cells, collagen, or elastin in spontaneously hypertensive arteries when compared to normotensive arteries. However, cells in the superior artery are significantly different in overall shape and surface features when compared to cells of small arteries. These differences in surface morphology of cells are present in hypertensive and normotensive vessels and suggest that superior and small mesenteric artery cells transmit load to the isotropic matrix in different ways. In the elasto-muscular superior artery, force is transmitted across digitations throughout the cell surface. In the muscular small artery, force is transmitted across the tapered, smooth cell surface. Springer-Verlag, 1992 Mesentery nationallicence Arteries nationallicence Muscle, smooth nationallicence Elastic fibers nationallicence Collagen nationallicence Hypertensive rats nationallicence Extracellular matrix, structures nationallicence Rat(SHR) nationallicence Walker-Caprioglio H. Department of Pharmacology, School of Medicine, University of New Mexico Albuquerque, 87131-5316, NM, USA aut Trotter J. Department of Anatomy, School of Medicine, University of New Mexico Albuquerque, 87131-5316, NM, USA aut Little S. Department of Pharmacology, School of Medicine, University of New Mexico Albuquerque, 87131-5316, NM, USA aut McGuffee L. Department of Pharmacology, School of Medicine, University of New Mexico Albuquerque, 87131-5316, NM, USA aut Cell and Tissue Research Springer-Verlag 269/1(1992-07-01), 141-149 0302-766X 269:1<141 1992 269 441 https://doi.org/10.1007/BF00384734 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00384734 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Walker-Caprioglio H. Department of Pharmacology, School of Medicine, University of New Mexico Albuquerque, 87131-5316, NM, USA aut NATIONALLICENCE 700 1- Trotter J. Department of Anatomy, School of Medicine, University of New Mexico Albuquerque, 87131-5316, NM, USA aut NATIONALLICENCE 700 1- Little S. Department of Pharmacology, School of Medicine, University of New Mexico Albuquerque, 87131-5316, NM, USA aut NATIONALLICENCE 700 1- McGuffee L. Department of Pharmacology, School of Medicine, University of New Mexico Albuquerque, 87131-5316, NM, USA aut NATIONALLICENCE 773 0- Cell and Tissue Research Springer-Verlag 269/1(1992-07-01), 141-149 0302-766X 269:1<141 1992 269 441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer