caa a22 4500 469083778 CHVBK 20180323132958.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00384722 doi (NATIONALLICENCE)springer-10.1007/BF00384722 The origin of the luteinizing hormone-releasing hormone (LHRH) neurons in newts ( Cynops pyrrhogaster ): the effect of olfactory placode ablation [Elektronische Daten] [Shizuko Murakami, Sakaé Kikuyama, Yasumasa Arai] Summary: Neurons containing luteinizing hormone-releasing hormone (LHRH) are first detected in newt embryos (Cynops pyrrhogaster) in the olfactory epithelium and ventromedial portion of the olfactory nerve, after which they sequentially appear in the intracerebral course of the terminal nerve at prometamorphosis, and in the septo-preoptic area at postmetamorphosis. In adults, however, LHRH-immunoreactive cells are rarely seen in the nasal region, and their distribution shifts into the brain, suggesting their migration. In order to ascertain the origin and possible migration route of these neurons in newt larvae, the effect of unilateral or bilateral olfactory placodectomy on the LHRH neuronal system has been studied. Removal of the olfactory placode results in the absence of LHRH-immunoreactive cells in the nasal and brain regions of the operated side, whereas the subsequent growth and the LHRH-immunoreactive cellular distribution in the contralateral side are identical to those of normal larvae. Following bilateral placodectomy, no LHRH immunoreactivity is detected on either side of the olfactory-brain axis. These results suggest that LHRH neurons of the newt, Cynops pyrrhogaster, originate in the olfactory placode and then migrate into the brain during embryonic development. Springer-Verlag, 1992 LHRH-containing neurons nationallicence Olfactory placode, origin nationallicence Terminal nerve nationallicence Development nationallicence Cynops pyrrhogaster (Urodela) nationallicence Murakami Shizuko Department of Anatomy, Juntendo University School of Medicine, Hongo, 113, Tokyo, Japan aut Kikuyama Sakaé Department of Biology, School of Education, Waseda University, 169, Shinjuku, Tokyo, Japan aut Arai Yasumasa Department of Anatomy, Juntendo University School of Medicine, Hongo, 113, Tokyo, Japan aut Cell and Tissue Research Springer-Verlag 269/1(1992-07-01), 21-27 0302-766X 269:1<21 1992 269 441 https://doi.org/10.1007/BF00384722 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00384722 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Murakami Shizuko Department of Anatomy, Juntendo University School of Medicine, Hongo, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Kikuyama Sakaé Department of Biology, School of Education, Waseda University, 169, Shinjuku, Tokyo, Japan aut NATIONALLICENCE 700 1- Arai Yasumasa Department of Anatomy, Juntendo University School of Medicine, Hongo, 113, Tokyo, Japan aut NATIONALLICENCE 773 0- Cell and Tissue Research Springer-Verlag 269/1(1992-07-01), 21-27 0302-766X 269:1<21 1992 269 441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer