caa a22 4500 46908393X CHVBK 20180323132959.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00353892 doi (NATIONALLICENCE)springer-10.1007/BF00353892 Distribution of the α2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues [Elektronische Daten] [Søren Moestrup, Jørgen Gliemann, Gorm Pallesen] Summary: The hepatic α1-macroglobulin receptor (α2MR)/low density lipoprotein receptor-related protein (LRP) binds and endocytoses α2-macroglobulin-proteinase complexes in plasma. In addition, it binds lipoproteins, a novel 40 kDa protein, and complexes between plasminogen activators and plasminogen activator inhibitor type-1. This study shows, for the first time, the tissue distribution of α2MR/LRP as determined by immunohistochemistry with specific monoclonal antibodies. The analysis revealed α2MR/LRP-expression in a restricted spectrum of cell types, including neurons and astrocytes in the central nervous system, epithelial cells of the gastrointestinal tract, smooth muscle cells, fibroblasts, Leydig cells in testis, granulosa cells in ovary, and dendritic interstitial cells of kidney. Monocytederived cells displayed marked α2MR/LRP expression in the phagocytes of liver, lung and lymphoid tissues, but no or low expression in antigen-presenting cells including Langerhans' cells of the skin. The high abundance of α2MR/LRP in certain cell types of most organs suggests two main routes for α2MR/LRP ligand clearance: (1) systemic removal in liver of circulating ligands, and (2) non-hepatic interstitial removal in different organs, including the brain. Springer-Verlag, 1992 α2-Macroglobulin receptor nationallicence Low-density lipoprotein receptor-related protein nationallicence Tissue distribution nationallicence Brain nationallicence Macrophages nationallicence Immunohistochemistry nationallicence Man nationallicence Moestrup Søren Institute of Medical Biochemistry, Aarhus University, DK-8000, Aarhus C, Denmark aut Gliemann Jørgen Institute of Medical Biochemistry, Aarhus University, DK-8000, Aarhus C, Denmark aut Pallesen Gorm Laboratory of Immunohistology, Institute of Pathology, Aarhus University Hospital, DK-8000, Aarhus C, Dermark aut Cell and Tissue Research Springer-Verlag 269/3(1992-09-01), 375-382 0302-766X 269:3<375 1992 269 441 https://doi.org/10.1007/BF00353892 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00353892 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moestrup Søren Institute of Medical Biochemistry, Aarhus University, DK-8000, Aarhus C, Denmark aut NATIONALLICENCE 700 1- Gliemann Jørgen Institute of Medical Biochemistry, Aarhus University, DK-8000, Aarhus C, Denmark aut NATIONALLICENCE 700 1- Pallesen Gorm Laboratory of Immunohistology, Institute of Pathology, Aarhus University Hospital, DK-8000, Aarhus C, Dermark aut NATIONALLICENCE 773 0- Cell and Tissue Research Springer-Verlag 269/3(1992-09-01), 375-382 0302-766X 269:3<375 1992 269 441 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer