caa a22 4500 469090642 CHVBK 20180323133016.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00464702 doi (NATIONALLICENCE)springer-10.1007/BF00464702 Pettersson I. Department of Medical Cell Genetics, Medical Nobel Institutet, Karolinska Institutet, Box 60 400, S-104 01, Stockholm, Sweden aut Methods of epitope mapping [Elektronische Daten] [I. Pettersson] Concluding remarks: It is important to remember that the merits of the different approaches to epitope mapping should be judged against the purpose of the study. A peptide specifically recognized by nearly all sera containing a certain autoimmune specificity [20, 21, 26], would most likely be selected for the detection of the anti-linear/continuous epitope fraction among those autoantibodies and could be highly useful for diagnostic purposes. This is true even if a majority of the antibodies were directed against conformational/discontinuous protein epitopes. If the purpose is to study the induction or maintenance of the autoimmune response, one would also have to look at and account for the conformation-dependent autoantibodies. There is also the possibility that some pathogenic autoantibodies could constitute a small fraction requiring the complete nucleic acid-protein complex as an antigen. In that case, the ‘pathogenic' epitope would not be identified nor mapped using the techniques discussed in this review. Kluwer Academic Publishers, 1992 autoantibody nationallicence autoantigen nationallicence B-cell epitope nationallicence Molecular Biology Reports Kluwer Academic Publishers 16/3(1992-06-01), 149-153 0301-4851 16:3<149 1992 16 11033 https://doi.org/10.1007/BF00464702 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00464702 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Pettersson I. Department of Medical Cell Genetics, Medical Nobel Institutet, Karolinska Institutet, Box 60 400, S-104 01, Stockholm, Sweden aut NATIONALLICENCE 773 0- Molecular Biology Reports Kluwer Academic Publishers 16/3(1992-06-01), 149-153 0301-4851 16:3<149 1992 16 11033 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer