caa a22 4500 469090847 CHVBK 20180323133016.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00419753 doi (NATIONALLICENCE)springer-10.1007/BF00419753 Effect of genetic background on the developmental expression of c-fos and c-myc in chicken [Elektronische Daten] [Jong Kim, Daniel Fletcher, Dennis Campion, H. Gaskins, Roger Dean] The developmental expression of the protooncogenes, c-fos and c-myc, in muscle and liver of 14-and 19-day embryos and 1-, 6-, 8-and 28-day-old chicks of Athens Canadian Random Bred (ACRB) Single Comb White Leghorn (SCWL) and Peterson X Arbor Acres commercial broiler (PXAA) was determined. For the three stocks of chicken, significant differences were found in c-fos and c-myc expression. For both muscle and liver, averaged across ages, abundance of c-fos RNA was highest in PXAA and lowest in ACRB with differences significant at the P<0.01 level. c-myc RNA levels were significantly higher (P<0.01) in PXAA than in ACRB or SCWL liver. Taken over the developmental period, expression of c-fos RNA in muscle increased at different rates between breeds from 14-day embryo levels to peak levels in 6- to 8-day-old chicks and declined in 28-day-old chicks. Levels of c-fos were much lower in liver and showed no consistent differences related to developmental stage. A steady decline in c-myc from 14-day embryo levels to 28-day-old chicks was found in both muscle and liver. This decline in c-myc levels generally parallels the decline in relative growth rates which occurs in all breeds over the developmental period. In liver, the fast growing PXAA had the highest levels of c-myc. c-fos, on the other hand, showed elevated levels in PXAA for both muscle and liver and distinctly different patterns between these two tissues over the developmental period, suggesting tissue-specific involvement in growth. Kluwer Academic Publishers, 1992 c-myc nationallicence c-fos nationallicence embryo nationallicence chick nationallicence muscle nationallicence liver nationallicence Kim Jong Department of Poultry Science, University of Georgia, 30602, Athens, GA, USA aut Fletcher Daniel Department of Poultry Science, University of Georgia, 30602, Athens, GA, USA aut Campion Dennis Department of Animal Sciences, University of Illinois, 61801, Urbana, IL, USA aut Gaskins H. The Jackson Laboratory, 04609, Bar Harbor, ME, USA aut Dean Roger Department of Animal and Dairy Science, University of Georgia, 30602, Athens, GA, USA aut Molecular Biology Reports Kluwer Academic Publishers 16/2(1992-05-01), 85-90 0301-4851 16:2<85 1992 16 11033 https://doi.org/10.1007/BF00419753 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00419753 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Jong Department of Poultry Science, University of Georgia, 30602, Athens, GA, USA aut NATIONALLICENCE 700 1- Fletcher Daniel Department of Poultry Science, University of Georgia, 30602, Athens, GA, USA aut NATIONALLICENCE 700 1- Campion Dennis Department of Animal Sciences, University of Illinois, 61801, Urbana, IL, USA aut NATIONALLICENCE 700 1- Gaskins H. The Jackson Laboratory, 04609, Bar Harbor, ME, USA aut NATIONALLICENCE 700 1- Dean Roger Department of Animal and Dairy Science, University of Georgia, 30602, Athens, GA, USA aut NATIONALLICENCE 773 0- Molecular Biology Reports Kluwer Academic Publishers 16/2(1992-05-01), 85-90 0301-4851 16:2<85 1992 16 11033 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer