caa a22 4500 469090871 CHVBK 20180323133016.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00419754 doi (NATIONALLICENCE)springer-10.1007/BF00419754 Nucleotide sequence and genomic structure analyses of the p70 subunit of the human Ku autoantigen: evidence for a family of genes encoding Ku (p70)-related polypeptides [Elektronische Daten] [Andrew Griffith, Joe Craft, Janine Evans, Tsuneyo Mimori, John Hardin] cDNA encoding the p70 polypeptide subunit of the human Ku autoantigen was isolated. In vitro expression analysis of the cDNA demonstrates that it encodes the entire open reading frame. Nucleotide sequence analysis and comparison to other previously described sequences indicate the existence of several single-nucleotide and amino acid polymorphisms. Southern blot analyses demonstrate the presence of multiple copies of homologous DNA sequences in the human genome. These data support the hypothesis that multiple genes encode a family of Ku(p70)-related polypeptides. Kluwer Academic Publishers, 1992 autoantibodies nationallicence DNA-binding protein nationallicence gene nationallicence Ku protein nationallicence recombinant DNA nationallicence systemic lupus erythematosus nationallicence Griffith Andrew Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA aut Craft Joe Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA aut Evans Janine Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA aut Mimori Tsuneyo Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA aut Hardin John Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA aut Molecular Biology Reports Kluwer Academic Publishers 16/2(1992-05-01), 91-97 0301-4851 16:2<91 1992 16 11033 https://doi.org/10.1007/BF00419754 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00419754 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Griffith Andrew Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA aut NATIONALLICENCE 700 1- Craft Joe Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA aut NATIONALLICENCE 700 1- Evans Janine Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA aut NATIONALLICENCE 700 1- Mimori Tsuneyo Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA aut NATIONALLICENCE 700 1- Hardin John Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, 06510, New Haven, CT, USA aut NATIONALLICENCE 773 0- Molecular Biology Reports Kluwer Academic Publishers 16/2(1992-05-01), 91-97 0301-4851 16:2<91 1992 16 11033 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer