caa a22 4500 469093013 CHVBK 20180323133023.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00580619 doi (NATIONALLICENCE)springer-10.1007/BF00580619 The receptor-mediated retention of resident proteins in the endoplasmic reticulum [Elektronische Daten] [David Vaux, Stephen Fuller] Conclusion: Overwhelming evidence has accumulated to support the bulk flow hypothesis which states that proteins entering the exocytic pathway will follow a default route to the plasma membrane unless they carry specific signals for receptor mediated diversion. The resident soluble and membrane proteins of the ER present a clear example of this signal mediated exception to bulk flow. Their study also provides insights relevant to retention or targetting signals operating later in the secretory pathway. The last few years have seen enormous progress in this field, in the delineation of the retention problem, the identification of the retention signal and recently in the identification of components of the retention machinery itself. The next few years hold the promise of a more complete understanding of the retention machinery and of the enigmatic cellular compartment in which it functions. Kluwer Academic Publishers, 1992 KDEL receptor nationallicence salvage compartment nationallicence retention signals nationallicence S. cerevisiae nationallicence mammalian cells nationallicence Vaux David The Cell Biology Programme, European Molecular Biology Laboratory, D6900, Heidelberg, Germany aut Fuller Stephen The Cell Biology Programme, European Molecular Biology Laboratory, D6900, Heidelberg, Germany aut Antonie van Leeuwenhoek Kluwer Academic Publishers 61/2(1992-02-01), 123-131 0003-6072 61:2<123 1992 61 10482 https://doi.org/10.1007/BF00580619 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00580619 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vaux David The Cell Biology Programme, European Molecular Biology Laboratory, D6900, Heidelberg, Germany aut NATIONALLICENCE 700 1- Fuller Stephen The Cell Biology Programme, European Molecular Biology Laboratory, D6900, Heidelberg, Germany aut NATIONALLICENCE 773 0- Antonie van Leeuwenhoek Kluwer Academic Publishers 61/2(1992-02-01), 123-131 0003-6072 61:2<123 1992 61 10482 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer