caa a22 4500 469093366 CHVBK 20180323133024.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF00572595 doi (NATIONALLICENCE)springer-10.1007/BF00572595 Evaluation of two unstructured mathematical models for the penicillin G fedbatch fermentation [Elektronische Daten] [Bart Nicolaï, Jan Van Impe, Peter Vanrolleghem, Joos Vandewalle] The mathematical model for the penicillin G fed-batch fermentation proposed by Heijnen et al. (1979) is compared with the model of Bajpai & Reuß (1980). Although the general structure of these models is similar, the difference in metabolic assumptions and specific growth and production kinetics results in a completely different behaviour towards product optimization. A detailed analysis of both models reveals some physical and biochemical shortcomings. It is shown that it is impossible to make a reliable estimation of the model parameters, only using experimental data of simple constant glucose feed rate fermentations with low initial substrate amount. However, it is demonstrated that some model parameters might be key factors in concluding whether or not altering the substrate feeding strategy has an important influence on the final amount of product. It is illustrated that feeding strategy optimization studies can be a tool in designing experiments for parameter estimation purposes. Kluwer Academic Publishers, 1992 biotechnological modeling nationallicence maintenance and endogenous metabolism nationallicence parameter estimation nationallicence penicillin fed-batch fermentation nationallicence unstructured model nationallicence Nicolaï Bart Agricultural Engineering Department, K.U. Leuven, Kardinaal Mercierlaan 92, B-3001, Heverlee, Belgium aut Van Impe Jan ESAT-Electrical Engineering Department, K.U. Leuven, Kardinaal Mercierlaan 94, B-3001, Heverlee, Belgium aut Vanrolleghem Peter Agricultural Engineering Department, R.U. Gent, Coupure Links 653, B-9000, Gent, Belgium aut Vandewalle Joos ESAT-Electrical Engineering Department, K.U. Leuven, Kardinaal Mercierlaan 94, B-3001, Heverlee, Belgium aut Antonie van Leeuwenhoek Kluwer Academic Publishers 62/4(1992-11-01), 273-283 0003-6072 62:4<273 1992 62 10482 https://doi.org/10.1007/BF00572595 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00572595 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nicolaï Bart Agricultural Engineering Department, K.U. Leuven, Kardinaal Mercierlaan 92, B-3001, Heverlee, Belgium aut NATIONALLICENCE 700 1- Van Impe Jan ESAT-Electrical Engineering Department, K.U. Leuven, Kardinaal Mercierlaan 94, B-3001, Heverlee, Belgium aut NATIONALLICENCE 700 1- Vanrolleghem Peter Agricultural Engineering Department, R.U. Gent, Coupure Links 653, B-9000, Gent, Belgium aut NATIONALLICENCE 700 1- Vandewalle Joos ESAT-Electrical Engineering Department, K.U. Leuven, Kardinaal Mercierlaan 94, B-3001, Heverlee, Belgium aut NATIONALLICENCE 773 0- Antonie van Leeuwenhoek Kluwer Academic Publishers 62/4(1992-11-01), 273-283 0003-6072 62:4<273 1992 62 10482 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer