caa a22 4500 469093404 CHVBK 20180323133024.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF00584467 doi (NATIONALLICENCE)springer-10.1007/BF00584467 Genetic approaches to the study of mitochondrial biogenesis in yeast [Elektronische Daten] [M. Bolotin-Fukuhara, L. Grivell] In contrast to most other organisms, the yeastSaccharomyces cerevisiae can survive without functional mitochondria. This ability has been exploited in genetic approaches to the study of mitochondrial biogenesis. In the last two decades, mitochondrial genetics have made major contributions to the identification of genes on the mitochondrial genome, the mapping of these genes and the establishment of structure-function relationships in the products they encode. In parallel, more than 200 complementation groups, corresponding to as many nuclear genes necessary for mitochondrial function or biogenesis have been described. Many of the latter are required for post-transcriptional events in mitochondrial gene expression, including the processing of mitochondrial pre-RNAs, the translation of mitochondrial mRNAs, or the assembly of mitochondrial translation products into the membrane. The aim of this review is to describe the genetic approaches used to unravel the intricacies of mitochondrial biogenesis and to summarize recent insights gained from their application. Kluwer Academic Publishers, 1992 mitochondrial DNA nationallicence mutational analysis nationallicence nucleo-mitochondrial interactions nationallicence gene expression nationallicence membrane assembly nationallicence respiratory deficiency nationallicence Bolotin-Fukuhara M. Laboratoire de Génétique Moléculaire, Institut de Génétique et Microbiologie, Université Paris-Sud, Centre d'Orsay, 91405, Orsay, France aut Grivell L. Section for Molecular Biology, Department of Molecular Cell Biology, University of Amsterdam, Kruislaan 318, 1098 SM, Amsterdam, The Netherlands aut Antonie van Leeuwenhoek Kluwer Academic Publishers 62/1-2(1992-08-01), 131-153 0003-6072 62:1-2<131 1992 62 10482 https://doi.org/10.1007/BF00584467 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00584467 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bolotin-Fukuhara M. Laboratoire de Génétique Moléculaire, Institut de Génétique et Microbiologie, Université Paris-Sud, Centre d'Orsay, 91405, Orsay, France aut NATIONALLICENCE 700 1- Grivell L. Section for Molecular Biology, Department of Molecular Cell Biology, University of Amsterdam, Kruislaan 318, 1098 SM, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Antonie van Leeuwenhoek Kluwer Academic Publishers 62/1-2(1992-08-01), 131-153 0003-6072 62:1-2<131 1992 62 10482 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer