caa a22 4500 469093447 CHVBK 20180323133024.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF00584464 doi (NATIONALLICENCE)springer-10.1007/BF00584464 Heterologous protein production in yeast [Elektronische Daten] [Gerd Gellissen, Karl Melber, Zbigniew Janowicz, Ulrike Dahlems, Ulrike Weydemann, Michael Piontek, Alexander Strasser, Cornelis Hollenberg] The exploitation of recombinant DNA technology to engineer expression systems for heterologous proteins represented a major task within the field of biotechnology during the last decade. Yeasts attracted the attention of molecular biologists because of properties most favourable for their use as hosts in heterologous protein production. Yeasts follow the general eukaryotic posttranslational modification pattern of expressed polypeptides, exhibit the ability to secrete heterologous proteins and benefit from an established fermentation technology. Aside from the baker's yeastSaccharomyces cerevisiae, an increasing number of alternative non-Saccharomyces yeast species are used as expression systems in basic research and for an industrial application. In the following review a selection from the different yeast systems is described and compared. Kluwer Academic Publishers, 1992 heterologous gene expression nationallicence non- Saccharomyces yeast nationallicence Saccharomyces cerevisiae nationallicence secretion nationallicence protein production nationallicence Gellissen Gerd Rhein Biotech GmbH, Eichsfelder Str. 11, 4000, Düsseldorf 13, Germany aut Melber Karl Rhein Biotech GmbH, Eichsfelder Str. 11, 4000, Düsseldorf 13, Germany aut Janowicz Zbigniew Rhein Biotech GmbH, Eichsfelder Str. 11, 4000, Düsseldorf 13, Germany aut Dahlems Ulrike Rhein Biotech GmbH, Eichsfelder Str. 11, 4000, Düsseldorf 13, Germany aut Weydemann Ulrike Rhein Biotech GmbH, Eichsfelder Str. 11, 4000, Düsseldorf 13, Germany aut Piontek Michael Rhein Biotech GmbH, Eichsfelder Str. 11, 4000, Düsseldorf 13, Germany aut Strasser Alexander Rhein Biotech GmbH, Eichsfelder Str. 11, 4000, Düsseldorf 13, Germany aut Hollenberg Cornelis Institut für Mikrobiologie, Heinrich-Heine-Universität, Universitätsstr. 1, 4000, Düsseldorf 1, Germany aut Antonie van Leeuwenhoek Kluwer Academic Publishers 62/1-2(1992-08-01), 79-93 0003-6072 62:1-2<79 1992 62 10482 https://doi.org/10.1007/BF00584464 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00584464 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gellissen Gerd Rhein Biotech GmbH, Eichsfelder Str. 11, 4000, Düsseldorf 13, Germany aut NATIONALLICENCE 700 1- Melber Karl Rhein Biotech GmbH, Eichsfelder Str. 11, 4000, Düsseldorf 13, Germany aut NATIONALLICENCE 700 1- Janowicz Zbigniew Rhein Biotech GmbH, Eichsfelder Str. 11, 4000, Düsseldorf 13, Germany aut NATIONALLICENCE 700 1- Dahlems Ulrike Rhein Biotech GmbH, Eichsfelder Str. 11, 4000, Düsseldorf 13, Germany aut NATIONALLICENCE 700 1- Weydemann Ulrike Rhein Biotech GmbH, Eichsfelder Str. 11, 4000, Düsseldorf 13, Germany aut NATIONALLICENCE 700 1- Piontek Michael Rhein Biotech GmbH, Eichsfelder Str. 11, 4000, Düsseldorf 13, Germany aut NATIONALLICENCE 700 1- Strasser Alexander Rhein Biotech GmbH, Eichsfelder Str. 11, 4000, Düsseldorf 13, Germany aut NATIONALLICENCE 700 1- Hollenberg Cornelis Institut für Mikrobiologie, Heinrich-Heine-Universität, Universitätsstr. 1, 4000, Düsseldorf 1, Germany aut NATIONALLICENCE 773 0- Antonie van Leeuwenhoek Kluwer Academic Publishers 62/1-2(1992-08-01), 79-93 0003-6072 62:1-2<79 1992 62 10482 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer