caa a22 4500 469093471 CHVBK 20180323133024.0 cr unu---uuuuu 170328e19920801xx s 000 0 eng 10.1007/BF00584458 doi (NATIONALLICENCE)springer-10.1007/BF00584458 Nuclear transport and nuclear pores in yeast [Elektronische Daten] [U. Nehrbass, E. Hurt] The central features of nuclear import have been conserved during evolution. In yeast the nuclear accumulation of proteins follows the same selective and active transport mechanisms known from higher eukaryotes. Yeast nuclear proteins contain nuclear localization sequences (NLS) which are presumably recognized by receptors in the cytoplasm and the nuclear envelope. Subsequent to this recognition step, nuclear proteins are translocated into the nucleus via the nuclear pore complexes. The structure of the yeast nuclear pore complex resembles that of higher eukaryotes. Recently, the first putative components of the yeast nuclear import machinery have been cloned and sequenced. The genetically amenable yeast system allows for an efficient structural and functional analysis of these components. Due to the evolutionary conservation potential insights into the nuclear import mechanisms in yeast can be transferred to higher eukaryotes. Thus, yeast can be considered as a eukaryotic model system to study nuclear transport. Kluwer Academic Publishers, 1992 Saccharomyces cerevisiae nationallicence nuclear pore complex nationallicence nuclear transport nationallicence nuclear localization sequence nationallicence nucleoporins nationallicence Nehrbass U. European Molecular Biology Laboratory, Meyerhofstraße 1, Postfach 10.2209, D-6900, Heidelberg, Germany aut Hurt E. European Molecular Biology Laboratory, Meyerhofstraße 1, Postfach 10.2209, D-6900, Heidelberg, Germany aut Antonie van Leeuwenhoek Kluwer Academic Publishers 62/1-2(1992-08-01), 3-14 0003-6072 62:1-2<3 1992 62 10482 https://doi.org/10.1007/BF00584458 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00584458 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nehrbass U. European Molecular Biology Laboratory, Meyerhofstraße 1, Postfach 10.2209, D-6900, Heidelberg, Germany aut NATIONALLICENCE 700 1- Hurt E. European Molecular Biology Laboratory, Meyerhofstraße 1, Postfach 10.2209, D-6900, Heidelberg, Germany aut NATIONALLICENCE 773 0- Antonie van Leeuwenhoek Kluwer Academic Publishers 62/1-2(1992-08-01), 3-14 0003-6072 62:1-2<3 1992 62 10482 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer