caa a22 4500 469093803 CHVBK 20180323133025.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576266 doi (NATIONALLICENCE)springer-10.1007/BF02576266 Cholinergic and adrenergic drugs affect delayed type hypersensitivity in C57BL/6 MICE [Elektronische Daten] [B. Günther, P. Clausing] Summary: The present study examined the influence of systemic administration of neuroactive drugs on delayed-type hypersensitivity (DTH) in C57BL/6 mice. The cholinergic agonist nicotine and the acetylcholineesterase inhibitor physostigmine decreased DTH, whereas the alpha-adrenergic agonist clonidine stimulated DTH. In contrast isoprenaline, a specific β-adrenergic agonist suppressed DTH. It is concluded from these observations that the autonomic nervous system modulates those processes governing DTH. It seems that the alpha-adrenergic subsystem stimulates, whereas the β-adrenergic subsystem and the parasympathicus inhibit DTH. Springer-Verlag, 1992 Delayed type hypersensitivity nationallicence Cholinergic drugs nationallicence Adrenergic drugs nationallicence Neuroimmune interactions nationallicence C57BL/6 mice nationallicence Günther B. Department of Animal Models, Institute of Microbiology and Experimental Therapy, Beutenbergstrasse 11, O-6900, Jena, Federal Republic of Germany aut Clausing P. Department of Animal Models, Institute of Microbiology and Experimental Therapy, Beutenbergstrasse 11, O-6900, Jena, Federal Republic of Germany aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 123-130 0300-9130 192:1<123 1992 192 433 https://doi.org/10.1007/BF02576266 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576266 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Günther B. Department of Animal Models, Institute of Microbiology and Experimental Therapy, Beutenbergstrasse 11, O-6900, Jena, Federal Republic of Germany aut NATIONALLICENCE 700 1- Clausing P. Department of Animal Models, Institute of Microbiology and Experimental Therapy, Beutenbergstrasse 11, O-6900, Jena, Federal Republic of Germany aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 123-130 0300-9130 192:1<123 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer