caa a22 4500 469093870 CHVBK 20180323133025.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576256 doi (NATIONALLICENCE)springer-10.1007/BF02576256 Intracranial pressure and cerebral perfusion pressure in experimental streptococcus pneumoniae meningitis [Elektronische Daten] [Kalman Goitein, Mervyn Shapiro] Summary: Clinical studies have demonstrated the prognostic importance of increased intracranial pressure in central nervous system infections. To delineate development of intracranial pressure in meningitis experiments were carried out in rabbits. Meningitis was induced by injectingstreptococcus pneumoniae bacteria into the cisterna magna and blood, and intracranial pressures were continuously recorded. In the experimental model, three stages were seen: incubation period (0-8h)—in which CSF becomes positive for the infecting organism and biochemical changes occur, but there are no hemodynamic or intracranial pressure changes; stage of slowly increasing intracranial pressure—because blood pressure remains normal, cerebral perfusion pressure is maintained adequate for cerebral metabolic need (9-24h); terminal stage (>25 h)—with hemodynamic collapse, critical reduction of cerebral perfusion pressure, cerebral ischemia, and death of the experimental animals. It is suggested that a similar sequence occurs in human disease. The clinical implication stresses the need for early recognition and treatment of intracranial hypertension as an important adjunct to antibiotic treatment of the infecting organism. Springer-Verlag, 1992 Meningitis-experimental nationallicence Intracranial pressure nationallicence Cerebral perfusion pressure nationallicence Streptococcus pneumoniae nationallicence Goitein Kalman Pediatric Intensive Care, Departments of Pediatrics and Clinical Microbiology, Hadassah University Hospital, Jerusalem, Israel aut Shapiro Mervyn Pediatric Intensive Care, Departments of Pediatrics and Clinical Microbiology, Hadassah University Hospital, Jerusalem, Israel aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 41-47 0300-9130 192:1<41 1992 192 433 https://doi.org/10.1007/BF02576256 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576256 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goitein Kalman Pediatric Intensive Care, Departments of Pediatrics and Clinical Microbiology, Hadassah University Hospital, Jerusalem, Israel aut NATIONALLICENCE 700 1- Shapiro Mervyn Pediatric Intensive Care, Departments of Pediatrics and Clinical Microbiology, Hadassah University Hospital, Jerusalem, Israel aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 41-47 0300-9130 192:1<41 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer