caa a22 4500 469093897 CHVBK 20180323133025.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576251 doi (NATIONALLICENCE)springer-10.1007/BF02576251 Effects of interleukin-1β on the renin-angiotensin-aldosterone system in rats [Elektronische Daten] [P. Andreis, G. Neri, V. Meneghelli, G. Mazzocchi, G. Nussdorfer] Summary: A bolus IP injection of interleukin-1β (IL-1β) (8 μg·kg−1) increased blood pressure and PRA without affecting plasma aldosterone (ALDO) concentration. IL-1β strongly attenuated angiotensin-II (ANG-II, 10−8 M)-stimulated ALDO secretion by both isolated zona glomerulosa (ZG) cells and capsular strips. These findings suggest that IL-1β exerts a twofold opposite action on the main components of the rat renin-angiotensin-aldosterone system: simultaneous stimulation of renin release by kidneys and inhibition of the stimulatory effect of ANG-II on ALDO production. At the highest concentrations (10−6/10−5 M), IL-1β was found to lower also basal ALDO output by isolated ZG cells, but not by capsular strips. However, in the presence of saralasin 10−8 M (a competitive inhibitor of ANG-II) and captopril 10−8 M (an angiotensin-I-converting enzyme inhibitor), IL-1β significantly reduced basal ALDO yield of capsular strips. These last results would suggest that IL-1β could also similarly affect the intraadrenal renin-angiotensin system, which seems to be involved in the local regulation of ZG secretory activity. Springer-Verlag, 1992 Interleukin-1β nationallicence Renin-angiotensin system nationallicence Zona glomerulosa nationallicence Aldosterone nationallicence Rat nationallicence Andreis P. Department of Anatomy, University of Padua, I-35121, Padua, Italy aut Neri G. Department of Anatomy, University of Padua, I-35121, Padua, Italy aut Meneghelli V. Department of Anatomy, University of Padua, I-35121, Padua, Italy aut Mazzocchi G. Department of Anatomy, University of Padua, I-35121, Padua, Italy aut Nussdorfer G. Department of Anatomy, University of Padua, I-35121, Padua, Italy aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 1-6 0300-9130 192:1<1 1992 192 433 https://doi.org/10.1007/BF02576251 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576251 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Andreis P. Department of Anatomy, University of Padua, I-35121, Padua, Italy aut NATIONALLICENCE 700 1- Neri G. Department of Anatomy, University of Padua, I-35121, Padua, Italy aut NATIONALLICENCE 700 1- Meneghelli V. Department of Anatomy, University of Padua, I-35121, Padua, Italy aut NATIONALLICENCE 700 1- Mazzocchi G. Department of Anatomy, University of Padua, I-35121, Padua, Italy aut NATIONALLICENCE 700 1- Nussdorfer G. Department of Anatomy, University of Padua, I-35121, Padua, Italy aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 1-6 0300-9130 192:1<1 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer