caa a22 4500 469093919 CHVBK 20180323133025.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576292 doi (NATIONALLICENCE)springer-10.1007/BF02576292 Effects of the serotonin-antagonist ketanserin on the function of ischaemic and normally perfused myocardium and modification by β-1-blockade in anaesthetized normotensive dogs [Elektronische Daten] [H. Schad, W. Heimisch, A. Barankay, S. Hesse, N. Mendler] Summary: The 5-HT-2 antagonist ketanserin (KAS) has been successfully used to treat acute hypertension in coronary bypass surgery. The present study was performed to investigate the effect of KAS on ischaemic myocardium. In 11 anaesthetized (piritramide) dogs, systolic contraction (sdL) and end-diastolic length (edL) of myocardium supplied by the left descending coronary artery (LAD) and the left circumflex coronary artery (LCX) were measured by sonomicrometry simultaneously with aortic pressure (AoP), left ventricular dP/dtmax and end-diastolic pressure (LVedP), heart rate (HR), stroke volume, and LAD flow (QLAD). Regional ischaemia to decrease sdLLAD (−48%) was achieved by LAD stenosis (QLAD −47%). Concomitantly, edLLAD increased by 8%. However, the other variables did not change. Then KAS was given i.v. (0.15+ 0.15+0.30+0.6mg/kg) at 15-min intervals. Following KAS, prestenotic sdLLAD recovered in a dose-dependent manner. LVedP and edLLAD decreased, sdLLCX increased, and the other variables were not affected. This functional recovery of ischaemic myocardium was attenuated by pretreatment with metoprolol (MET, 1 mg/kg) prior to LAD stenosis. The ischaemic area was not irreversibly damaged, however, as proven by the recovery of prestenotic sdLLAD values after release of the stenosis. The improved systolic shortening of ischaemic myocardium following KAS did not result from restored QLAD due to post-stenotic vasodilation or break up of platelet aggregates (QLAD did not increase) or from reduced afterload (AoP did not decrease). Obviously, it was mediated by β-1-receptors, as shown by the attenuation of the beneficial effect of KAS by pretreatment with MET. Springer-Verlag, 1992 Ketanserin nationallicence Metoprolol nationallicence Ischaemic myocardium nationallicence Anaesthetized dogs nationallicence Schad H. Klinik für Herz- und Gefässchirurgie, Deutsches Herzzentrum München, Lothstrasse 11, W-8000, München 2, Federal Republic of Germany aut Heimisch W. Klinik für Herz- und Gefässchirurgie, Deutsches Herzzentrum München, Lothstrasse 11, W-8000, München 2, Federal Republic of Germany aut Barankay A. Institut für Anästhesiologie, Deutsches Herzzentrum München, Lothstrasse 11, W-8000, München 2, Federal Republic of Germany aut Hesse S. Klinik für Herz- und Gefässchirurgie, Deutsches Herzzentrum München, Lothstrasse 11, W-8000, München 2, Federal Republic of Germany aut Mendler N. Klinik für Herz- und Gefässchirurgie, Deutsches Herzzentrum München, Lothstrasse 11, W-8000, München 2, Federal Republic of Germany aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 355-365 0300-9130 192:1<355 1992 192 433 https://doi.org/10.1007/BF02576292 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576292 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schad H. Klinik für Herz- und Gefässchirurgie, Deutsches Herzzentrum München, Lothstrasse 11, W-8000, München 2, Federal Republic of Germany aut NATIONALLICENCE 700 1- Heimisch W. Klinik für Herz- und Gefässchirurgie, Deutsches Herzzentrum München, Lothstrasse 11, W-8000, München 2, Federal Republic of Germany aut NATIONALLICENCE 700 1- Barankay A. Institut für Anästhesiologie, Deutsches Herzzentrum München, Lothstrasse 11, W-8000, München 2, Federal Republic of Germany aut NATIONALLICENCE 700 1- Hesse S. Klinik für Herz- und Gefässchirurgie, Deutsches Herzzentrum München, Lothstrasse 11, W-8000, München 2, Federal Republic of Germany aut NATIONALLICENCE 700 1- Mendler N. Klinik für Herz- und Gefässchirurgie, Deutsches Herzzentrum München, Lothstrasse 11, W-8000, München 2, Federal Republic of Germany aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 355-365 0300-9130 192:1<355 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer