caa a22 4500 469093943 CHVBK 20180323133025.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576298 doi (NATIONALLICENCE)springer-10.1007/BF02576298 Concentrations of d -lactate and its related metabolic intermediates in liver, blood, and muscle of diabetic and starved rats [Elektronische Daten] [Y. Kondoh, M. Kawase, Y. Kawakami, S. Ohmori] Summary: This is a report investigating the methylglyoxal (MG) bypass in animals, by whichd-lactate is produced from triosephosphate via MG. Rats were made diabetic using streptozotocin or starved for 72 h.d-Lactate and various metabolites related to it, such asl-lactate, pyruvate, methylglyoxal, glucose, and inorganic phosphate, were measured in the blood plasma, liver, and skeletal muscle of the rats. Diabetic and starved rats had significantly higher levels ofd-lactate in plasma, liver, and skeletal muscle compared with the control group. In contrast, pyruvate levels in plasma, liver, and skeletal muscle was markedly lower than normal in diabetic and starved rats.l-Lactate level lowered markedly in plasma, liver, and skeletal muscle of starved rats and elevated in liver of diabetic rats. Differences between plasmal-lactate level for diabetes and control were not significant. MG level was significantly elevated in plasma and depressed in livers and muscles of starved rats as well as livers of diabetic rats. Hepatic glycerol content was markedly increased in those states. Enzyme activities related tod- andl-lactate, such as pyruvate kinase, phosphofructokinase, aldolase, and glyoxalase I, were measured in the livers of these rats. Pyruvate kinase activity decreased in these states, but other enzyme activities showed no significant changes.d-Lactate was much more excreted thanl-lactate in the urine of diabetic and fasted rats compared with normal rats. Springer-Verlag, 1992 d -lactate nationallicence l -lactate nationallicence Methylglyoxal nationallicence Diabetic rat nationallicence Starved rat nationallicence Kondoh Y. Faculty of Pharmaceutial, Sciences, Department of Physiological Chemistry, Okayama University, Tsushima-Naka-1, Japan aut Kawase M. Faculty of Pharmaceutial, Sciences, Department of Physiological Chemistry, Okayama University, Tsushima-Naka-1, Japan aut Kawakami Y. Faculty of Pharmaceutial, Sciences, Department of Physiological Chemistry, Okayama University, Tsushima-Naka-1, Japan aut Ohmori S. Faculty of Pharmaceutial, Sciences, Department of Physiological Chemistry, Okayama University, Tsushima-Naka-1, Japan aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 407-414 0300-9130 192:1<407 1992 192 433 https://doi.org/10.1007/BF02576298 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576298 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kondoh Y. Faculty of Pharmaceutial, Sciences, Department of Physiological Chemistry, Okayama University, Tsushima-Naka-1, Japan aut NATIONALLICENCE 700 1- Kawase M. Faculty of Pharmaceutial, Sciences, Department of Physiological Chemistry, Okayama University, Tsushima-Naka-1, Japan aut NATIONALLICENCE 700 1- Kawakami Y. Faculty of Pharmaceutial, Sciences, Department of Physiological Chemistry, Okayama University, Tsushima-Naka-1, Japan aut NATIONALLICENCE 700 1- Ohmori S. Faculty of Pharmaceutial, Sciences, Department of Physiological Chemistry, Okayama University, Tsushima-Naka-1, Japan aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 407-414 0300-9130 192:1<407 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer