caa a22 4500 469093994 CHVBK 20180323133025.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576302 doi (NATIONALLICENCE)springer-10.1007/BF02576302 Effect of centrally administered enkephalins on carrageenin-induced paw oedema in rats [Elektronische Daten] [S. Bhattacharya, M. Saraswati, A. Sen] Summary: Intracerebroventricularly (icv) administered met-enkephalin, leuenkephalin, and morphine induced dose-related attenuation of carrageenin-induced acute paw oedema in rats. Naloxone (10 μ, icv) antagonized the anti-inflammatory effects of the enkephalins (20 μg) and morphine (20 μg), but itself induced an anti-inflammatory effect at a higher dose (50 μg, icv). The anti-inflammatory effects of the enkephalins, morphine, and the high dose of naloxone were significantly inhibited by metyrapone, an inhibitor of endogenous corticoid synthesis. The icv-administered doses of the enkephalins and morphine induced insignificant inflammation-attenuating effects when administered i.p. Results suggest that the anti-inflammatory effects of the enkephalins and morphine are exerted through central opiate receptors. Furthermore, the inflammation-attenuating effects of these drugs and the higher dose of naloxone appear to be dependent upon endogenous corticoids, suggesting that activation of the hypothalamo-pituitary-adrenocortical axis may be involved. Springer-Verlag, 1992 Carrageenin oedema nationallicence Enkephalins nationallicence Morphine nationallicence Naloxone nationallicence Adrenal cortex nationallicence Bhattacharya S. Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, 221005, Varanasi, India aut Saraswati M. Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, 221005, Varanasi, India aut Sen A. Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, 221005, Varanasi, India aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 443-449 0300-9130 192:1<443 1992 192 433 https://doi.org/10.1007/BF02576302 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576302 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bhattacharya S. Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, 221005, Varanasi, India aut NATIONALLICENCE 700 1- Saraswati M. Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, 221005, Varanasi, India aut NATIONALLICENCE 700 1- Sen A. Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, 221005, Varanasi, India aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 443-449 0300-9130 192:1<443 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer