caa a22 4500 46909401X CHVBK 20180323133025.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576277 doi (NATIONALLICENCE)springer-10.1007/BF02576277 Preventive effect of β-analyl- l -histidinato zinc on bone metabolism in rats fed on low-calcium and vitamin D-deficient diets [Elektronische Daten] [Y. Segawa, N. Tsuzuike, E. Tagashira, M. Yamaguchi] Summary: The effect of β-alanyl-l-histidinato zinc (AHZ) on bone metabolism in the femoral diaphysis of rats fed on low-calcium and vitamin D-deficient diets was investigated. Rats were orally administered AHZ (10, 30, and 100 mg/kg per day) for 14 days and were killed on the 15th day. Feeding with low-calcium and vitamin D-deficient diets caused a significant decrease in serum 25-hydroxy-vitamin D3, calcium, and inorganic phosphorus concentrations. These decreases were not prevented by AHZ administration. Meanwhile, the femoral-diaphyseal calcium and phosphorus contents were significantly reduced by feeding with the dificient diets. Decrease in bone calcium content was significantly prevented by the doses of 30 and 100 mg AHZ/kg. Furthermore, the dose of 100 mg AHZ/kg produced a significant increase in bone deoxyribonucleic acid (DNA) content and alkaline phosphatase activity in rats fed on the deficient diets. Bone zinc content in the deficient rats was significantly increased by the doses of AHZ (30 and 100 mg/kg). The present results suggest that oral administration of AHZ has a preventive effect in the development of deteriorating bone metabolism in rats fed on low-calcium and vitamin D-deficient diets. Springer-Verlag, 1992 β-Analyl- l -histidinato zinc nationallicence Bone metabolism nationallicence Calcium nationallicence DNA nationallicence Rat femur nationallicence Segawa Y. Department of Pharmacology, Central Research Laboratories, Zeria Pharmaceutical Co., Saitama, Japan aut Tsuzuike N. Department of Pharmacology, Central Research Laboratories, Zeria Pharmaceutical Co., Saitama, Japan aut Tagashira E. Department of Pharmacology, Central Research Laboratories, Zeria Pharmaceutical Co., Saitama, Japan aut Yamaguchi M. Laboratory of Metabolism and Endocrinology Graduate School of Nutritional Sciences, University of Shizuoka, 52-1 Yada, 422, Shizuoka, Japan aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 213-219 0300-9130 192:1<213 1992 192 433 https://doi.org/10.1007/BF02576277 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576277 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Segawa Y. Department of Pharmacology, Central Research Laboratories, Zeria Pharmaceutical Co., Saitama, Japan aut NATIONALLICENCE 700 1- Tsuzuike N. Department of Pharmacology, Central Research Laboratories, Zeria Pharmaceutical Co., Saitama, Japan aut NATIONALLICENCE 700 1- Tagashira E. Department of Pharmacology, Central Research Laboratories, Zeria Pharmaceutical Co., Saitama, Japan aut NATIONALLICENCE 700 1- Yamaguchi M. Laboratory of Metabolism and Endocrinology Graduate School of Nutritional Sciences, University of Shizuoka, 52-1 Yada, 422, Shizuoka, Japan aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 213-219 0300-9130 192:1<213 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer